Biomarkers for Predicting Malignant Pleural Mesothelioma in a Mexican Population

International Journal of Medical Sciences
Guadalupe Aguilar-MadridGeorg Johnen

Abstract

Background: Diagnosis of malignant pleural mesothelioma (MPM) remains a challenge, especially when resources in pathology are limited. The study aimed to evaluate cost-effective tumor markers to predict the probability of MPM in plasma samples in order to accelerate the diagnostic workup of the tissue of potential cases. Methods: We conducted a case-control study stratified by gender, which included 75 incident cases with MPM from three Mexican hospitals and 240 controls frequency-matched by age and year of blood drawing. Plasma samples were obtained to determine mesothelin, calretinin, and thrombomodulin using enzyme-linked immunosorbent assays (ELISAs). We estimated the performance of the markers based on the area under the curve (AUC) and predicted the probability of an MPM diagnosis of a potential case based on the marker concentrations. Results: Mesothelin and calretinin, but not thrombomodulin were significant predictors of a diagnosis of MPM with AUCs of 0.90 (95% CI: 0.85-0.95), 0.88 (95% CI: 0.82-0.94), and 0.51 (95% CI: 0.41-0.61) in males, respectively. For MPM diagnosis in men we estimated a true positive rate of 0.79 and a false positive rate of 0.11 for mesothelin. The corresponding figures for calretinin were 0.8...Continue Reading

Citations

Jul 31, 2020·BMC Research Notes·Martin LehnertUNKNOWN MoMar-Study Group
Jul 24, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Harvey I PassChandra M Goparaju
Oct 6, 2020·Thoracic Surgery Clinics·Harvey I PassChandra M Goparaju

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Methods Mentioned

BETA
blood drawing
ELISAs
ELISA

Software Mentioned

MoMar
SAS

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