Biomarkers in Coronary Artery Bypass Surgery: Ready for Prime Time and Outcome Prediction?

Frontiers in Cardiovascular Medicine
Alessandro ParolariElena Tremoli

Abstract

Coronary artery bypass surgery (CABG) is still one of the most frequently performed surgical procedures all over the world. The results of this procedure have been constantly improved over the years with low perioperative mortality rates, with relatively low complication rates. To further improve these outstanding results, the clinicians focused their attention at biomarkers as outcome predictors. Although biological testing for disease prediction has already been discussed many times, the role of biomarkers in outcome prediction after CABG is still controversial. In this article, we reviewed the current knowledge regarding the role of genetic and dynamic biomarkers and their possible association with the occurrence of adverse clinical outcomes after CABG. We also took into consideration that the molecular pathway activation and the possible imbalance may affect hard outcomes and graft patency. We analyzed biomarkers classified in two different categories depending on their possibility to change over time: genetic markers and dynamic markers. Moreover, we evaluated these markers by dividing them, into sub-categories, such as inflammation, hemostasis, renin-angiotensin, endothelial function, and other pathways. We showed that bi...Continue Reading

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Citations

Mar 4, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Ming YangJi-Wu Zhou
Jan 24, 2021·Journal of Cardiac Surgery·Perfusionist Tülay Aydınİsmail Koyuncu

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Methods Mentioned

BETA
coronary artery bypass
coronary bypass

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