Biomarkers in diverticular diseases of the colon

Digestive Diseases
Antonio Tursi

Abstract

Recent data found that diverticular disease (DD) of the colon shows similarities with inflammatory bowel diseases (IBD). In particular, the detection of microscopic inflammation and the clinical response to mesalazine seem to confirm the hypothesis that inflammation may be a key point for the appearance of symptoms and development of complications. In light of this hypothesis, several studies have recently focused their attention on the role of biomarkers in predicting and monitoring the course of the disease. C-reactive protein (CRP), white blood cell count, erythrocyte sedimentation rate, and fecal calprotectin (FC) have therefore been investigated. As in IBD, CRP seems to be the most effective marker of histological and clinical severity of the disease. In particular, CRP below 50 mg/l suggests an acute uncomplicated diverticulitis (AUD), whereas CRP higher than 200 mg/l is a strong indicator of DD complicated by perforation. As in IBD, FC seems to be a noninvasive sensitive marker of DD severity. In particular, FC may show slight increased valued already in symptomatic uncomplicated DD (SUDD) (FC value ≥15 μg/ml seems to be predictive of SUDD). As expected, FC shows higher values in AUD (FC value ≥60 μg/ml seems to be predi...Continue Reading

References

Jan 1, 1993·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·H Birkedal-HansenJ A Engler
Mar 10, 2001·Clinical Pharmacology and Therapeutics·UNKNOWN Biomarkers Definitions Working Group.
Oct 31, 2002·Best Practice & Research. Clinical Gastroenterology·Stephanie Jun, Neil Stollman
Oct 18, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·F CostaG Maltinti
Mar 3, 2004·Diseases of the Colon and Rectum·Toshiki MimuraSylvia L F Pender
May 15, 2004·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Jose M PereiraGiovanna Casola
Oct 6, 2006·International Journal of Colorectal Disease·U KlingeV Schumpelick
Jan 16, 2007·Alimentary Pharmacology & Therapeutics·D DesaiW J Sandborn
May 1, 2007·Digestive Diseases and Sciences·Raffaele PezzilliRoberto Corinaldesi
Jan 31, 2008·Digestive Diseases and Sciences·Antonio TursiFabio Aiello
Mar 19, 2008·Journal of Clinical Gastroenterology·Antonio TursiFabio Aiello
Sep 2, 2008·Scandinavian Journal of Gastroenterology·Rossella CianciGuido Costamagna
Oct 22, 2008·Journal of Clinical Gastroenterology·William B Hale, UNKNOWN NDSG
Oct 23, 2008·International Journal of Colorectal Disease·Antonio TursiFabio Aiello
Nov 20, 2008·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·P F RidgwayK Mealy
May 21, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J SimpsonR C Spiller
Jun 25, 2009·Alimentary Pharmacology & Therapeutics·A Tursi, S Papagrigoriadis
May 8, 2010·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Desmond C Winter
May 21, 2010·Diseases of the Colon and Rectum·David A EtzioniMaher A Abbas
May 21, 2010·Diseases of the Colon and Rectum·Wytze LamérisMarja A Boermeester
May 21, 2010·Journal of Clinical Gastroenterology·Antonio TursiFabio Aiello
Jul 21, 2010·World Journal of Surgery·S A KäserChristoph A Maurer
Dec 8, 2010·Alimentary Pharmacology & Therapeutics·A TursiG Brandimarte
Dec 15, 2010·Annals of Emergency Medicine·Brigitte M BaumannMichael C Farner
Jan 12, 2011·Digestive Diseases and Sciences·Luca ElliLuca Piodi
Feb 10, 2011·Diseases of the Colon and Rectum·Jason F HallDavid J Schoetz
Feb 25, 2011·Annals of Surgery·Caroline S AndewegHarry van Goor

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Citations

Oct 7, 2015·Digestive Diseases and Sciences·George F Longstreth, Ryan S Tieu
Oct 15, 2013·International Journal of Cancer. Journal International Du Cancer·Helen SwedeRichard G Stevens
Feb 19, 2013·Alimentary Pharmacology & Therapeutics·W KruisUNKNOWN German SAG-20 Study Group
Mar 31, 2016·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Mehmet Nesim AktasLevent Filik
May 29, 2015·Arquivos De Gastroenterologia·Lorete Maria da Silva KotzePaulo Gustavo Kotze
Jun 7, 2017·Nature Communications·Snaevar SigurdssonKari Stefansson
Sep 14, 2016·Journal of Clinical Gastroenterology·Antonella GalloGiovanni Cammarota
Sep 14, 2016·Journal of Clinical Gastroenterology·Knut-Arne Wensaas, Amrit Pali Hungin
Feb 1, 2019·Terapevticheskiĭ arkhiv·N A FadeevaA I Parfenov
Mar 29, 2020·Nature Reviews. Disease Primers·Antonio TursiSilvio Danese
Dec 19, 2013·Expert Review of Gastroenterology & Hepatology·Emanuel Burri, Christoph Beglinger
Apr 14, 2015·Terapevticheskiĭ arkhiv·M F OsipenkoE A Lyalyukova
Jul 29, 2015·World Journal of Gastroenterology : WJG·Luca NespoliLuca Gianotti
Jan 29, 2021·Medicina·Angelo ViscidoGiovanni Latella
Aug 17, 2021·Current Problems in Surgery·Nicholas FarkasMirza Khurrum Baig

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