Biomarkers in localized prostate cancer

Future Oncology
Matteo FerroOttavio De Cobelli

Abstract

Biomarkers can improve prostate cancer diagnosis and treatment. Accuracy of prostate-specific antigen (PSA) for early diagnosis of prostate cancer is not satisfactory, as it is an organ- but not cancer-specific biomarker, and it can be improved by using models that incorporate PSA along with other test results, such as prostate cancer antigen 3, the molecular forms of PSA (proPSA, benign PSA and intact PSA), as well as kallikreins. Recent reports suggest that new tools may be provided by metabolomic studies as shown by preliminary data on sarcosine. Additional molecular biomarkers have been identified by the use of genomics, proteomics and metabolomics. We review the most relevant biomarkers for early diagnosis and management of localized prostate cancer.

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Citations

Sep 15, 2016·Future Oncology·Matteo FerroOttavio De Cobelli
Apr 26, 2019·The Cochrane Database of Systematic Reviews·Frank-Jan H DrostIvo G Schoots
Mar 13, 2019·Metabolites·Nuria Gómez-CebriánLeonor Puchades-Carrasco
May 10, 2020·Medicine·Meenal SharmaHiroshi Miyamoto
Aug 15, 2020·Journal of Laboratory Physicians·Chandan Kumar NathPurnima Rajkhowa
Apr 9, 2019·Expert Review of Molecular Diagnostics·Giuseppe LucarelliMichele Battaglia
Jun 27, 2019·International Journal of Cancer. Journal International Du Cancer·Hongzhen LiGriffin P Rodgers
Feb 19, 2020·Current Pharmaceutical Design·Majid AssadiHojjat Ahmadzadehfar

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Methods Mentioned

BETA
biopsy
biopsies
PCR

Software Mentioned

Prolaris
DOCUMENT

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