PMID: 11906843Mar 22, 2002Paper

Biomarkers in molecular epidemiology studies for health risk prediction

Mutation Research
S Bonassi, William W Au

Abstract

The field of molecular epidemiology is very promising, as sophisticated techniques are being developed to address etiology, genetic susceptibility and mechanisms for induction of disease. The use of biomarkers plays a key role in these investigations because the information can be used to predict the development of disease and to implement disease prevention programs. However, as emphasized by Frederica P. Perera, the field is strewn with studies either that failed to use validated biomarkers or whose designs did not adequately consider the biology of the endpoints, and the availability of validated biomarkers of health risk is still limited. In this review, we have briefly described the usefulness of certain biomarkers for the documentation of exposure and early biological effects, with special concern for the prediction of cancer. An emphasis is placed on understanding the biological and health significance of biomarkers. By building reliable biomarker databases, a promising future is the integration of information from the genome programs to expand the scientific frontiers on etiology, health risk prediction and prevention of environmental disease.

References

Sep 1, 1978·Mutation Research·E Gebhart, H Kappauf
Aug 7, 1991·JAMA : the Journal of the American Medical Association·P G Shields, C C Harris
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D PinkelJ Gray
Feb 1, 1985·Mutation Research·M Fenech, A A Morley
Apr 1, 1997·Nature Genetics·F MitelmanB Johansson
Dec 24, 1997·American Journal of Epidemiology·C B Ambrosone, F F Kadlubar
Aug 14, 1998·Environmental Health Perspectives·M T Smith, L Zhang
Apr 9, 1999·International Journal of Epidemiology·M BlettnerC Friedenreich
May 26, 1999·Environmental Health Perspectives·W W AuM S Legator
Jan 15, 2000·Mutation Research·M HollsteinP Hainaut
Mar 29, 2000·Environmental and Molecular Mutagenesis·R R TiceY F Sasaki
Apr 20, 2000·Journal of the National Cancer Institute·F P Perera
Jun 8, 2000·Journal of the National Cancer Institute·M S KopreskiC D Gocke
Oct 31, 2000·International Journal of Cancer. Journal International Du Cancer·P Vineis, F Perera
Jan 4, 2001·Journal of Exposure Analysis and Environmental Epidemiology·L L Needham, K Sexton
Feb 15, 2001·Environmental and Molecular Mutagenesis·S A SalamaW W Au
Apr 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·A BardelliC Lengauer
Aug 17, 2001·Mutation Research·S BonassiR Puntoni
Oct 18, 2001·Radiation Research·M DuranteF A Cucinotta
Jan 1, 2001·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·V HaufroidD Lison

❮ Previous
Next ❯

Citations

Dec 4, 2003·Mutation Research·William W AuStephen K Tyring
Dec 4, 2003·Mutation Research·Hannu Norppa
Oct 1, 2002·Environmental Toxicology and Pharmacology·Farhat N JafferyP N Viswanathan
Nov 20, 2002·Mutation Research·I Sari-MinodierA Botta
Jun 6, 2003·Mutation Research·Nina T HollandMaria Bastaki
Aug 13, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Rani SauriasariKeiki Ogino
Sep 24, 2004·International Journal of Environmental Health Research·Irena SutiakováJana Porácová
Sep 12, 2012·International Journal of Environmental Health Research·Kristina VoigtKarl-Werner Schramm
Dec 16, 2011·Environmental Health Perspectives·Paul J Lioy, Stephen M Rappaport
Nov 25, 2003·Environmental Health Perspectives·William W AuCarlos H Sierra-Torres
May 27, 2004·Radiation Research·James D TuckerLouise H Lutze-Mann
Mar 25, 2009·Journal of Clinical Biochemistry and Nutrition·Noriko SakanoKeiki Ogino
Oct 30, 2009·International Journal of Molecular Sciences·Carla M SáCristina Pereira-Wilson
Jul 10, 2010·Radiation and Environmental Biophysics·Marcela Maria Pereira de Lemos PintoAdemir Amaral
Feb 9, 2016·Free Radical Biology & Medicine·N V MargaritelisM G Nikolaidis
Mar 23, 2011·Ecotoxicology and Environmental Safety·Carla Maria Lima SombraCláudia Pessoa
Dec 19, 2006·International Journal of Hygiene and Environmental Health·William W Au
Mar 4, 2011·Environmental and Molecular Mutagenesis·Emiliano BassoAntonella Testa
May 12, 2004·Journal of Clinical Epidemiology·Daniel J KimGraham A Colditz
Sep 16, 2006·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Gerhard Scherer
Jun 23, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Marco Durante
Nov 25, 2003·International Journal of Hygiene and Environmental Health·Nohelia Cajas-SalazarWilliam W Au
Aug 11, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Serafina PerroneGiuseppe Buonocore
Apr 5, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Christian GinzkeyNorbert H Kleinsasser
Jun 9, 2012·Mutation Research·Eileen PernotElisabeth Cardis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.