Biomarkers in Obesity: Serum Myeloperoxidase and Traditional Cardiac Risk Parameters

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
D C K BoratoJ C R Vellosa

Abstract

Chronic low-grade inflammation, combined with traditional cardiovascular risk factors, is common in obesity, providing systemic inflammation that is associated with increased cardiovascular risk. Studies have shown serum mieloperoxidase as a potential biomarker and its clinical applicability for evaluating cardiovascular risk. This study aimed to evaluate the MPO in obese individuals, with or without systemic inflammation and potential cardiovascular risk, as well as correlating MPO with some classic cardiovascular risk parameters. Inflammatory and cardiovascular risk markers, as well as different biochemical and hematological laboratory parameters, were analyzed. The volunteers were divided into 3 groups according to the presence (hs-CRP>3 mg/L) or absence (hs-CRP<3 mg/L) of systemic inflammation and possible cardiovascular risk. MPO was significantly increased (p<0.05) in the obese individuals with systemic inflammation. A significant increase (p<0.05) in the following biochemical parameters: glucose, HbA1c, triglycerides, non-HDL, TG/HDL was observed, and a significant decrease (p<0.01) in HDL was observed. Significant increases in the counts of total leukocytes, neutrophils and monocytes (p<0.01), as well as elevated blood ...Continue Reading

Citations

Apr 2, 2016·Oxidative Medicine and Cellular Longevity·K S Petersen, C Smith
Mar 7, 2018·Lipids in Health and Disease·Anita SzentpéteriMariann Harangi
Nov 26, 2019·Journal of Food Science·Yu QianHuayi Suo
Jul 2, 2017·Clinical Science·John J Reho, Kamal Rahmouni
Apr 20, 2018·Medical Sciences : Open Access Journal·Amjad A KhanArshad H Rahmani
Jul 30, 2018·Molecular Biology Reports·Mohammad AliSubrata K Biswas
Sep 2, 2017·Scientific Reports·L Rocha-PenhaV C Sandrim
Jun 21, 2018·Reviews in Endocrine & Metabolic Disorders·Kyoung-Jin ChungAntonios Chatzigeorgiou

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