Biomarkers in posttraumatic stress disorder: overview and implications for future research

Disease Markers
U SchmidtCarsten T Wotjak

Abstract

PTSD can develop in the aftermath of traumatic incidents like combat, sexual abuse, or life threatening accidents. Unfortunately, there are still no biomarkers for this debilitating anxiety disorder in clinical use. Anyhow, there are numerous studies describing potential PTSD biomarkers, some of which might progress to the point of practical use in the future. Here, we outline and comment on some of the most prominent findings on potential imaging, psychological, endocrine, and molecular PTSD biomarkers and classify them into risk, disease, and therapy markers. Since for most of these potential PTSD markers a causal role in PTSD has been demonstrated or at least postulated, this review also gives an overview on the current state of research on PTSD pathobiology.

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Related Concepts

Post-Traumatic Stress Disorder
Hypothalamo-Hypophyseal System
Endocrine System
Delayed Onset Post-Traumatic Stress Disorder
Pituitary-Adrenal System
Structure of Subiculum Hippocampi
Victim of Sexual Abuse
Anxiety Disorders
Skin Endocrine Disorder
Viral Markers

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