Biomarkers in the prediction of contrast media induced nephropathy - the BITCOIN study

PloS One
Felix S SeibertTimm H Westhoff

Abstract

Subjects with chronic kidney disease are at increased risk for contrast-induced acute kidney injury (CI-AKI). Risk stratification is traditionally based on glomerular filtration rate (GFR) and proteinuria. The present trial examines, whether tubular and inflammatory biomarkers are able to identify subjects at increased risk as well. We performed a prospective study in 490 patients undergoing coronary angiography. An increase of serum creatinine concentration ≥ 0.3 mg/dl from baseline to day 2-3 was defined as primary endpoint (CI-AKI). Urinary neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), and calprotectin were assessed < 24h before coronary angiography. Prognostic accuracy was assessed by receiver operating characteristics (ROC) calculations. 30 (6.1%) patients suffered from CI-AKI (27 AKIN stage I, 3 AKIN stage II, 0 AKIN stage III). Those subjects who developed CI-AKI had 3.1 fold higher baseline urinary NGAL/creatinine ratios than those without CI-AKI (60.8 [IQR 18.7-93.1] μg/mg vs. 19.9 [IQR 12.3-38.9] μg/mg, p = 0.001). In those subjects without clinically overt CKD (eGFR > 60 ml/min, urinary albumin creatinine ratio <30 mg/g), the NGAL/creatinine ratio was 2.6 higher in CI-AKI vs. no...Continue Reading

References

Mar 16, 2005·Toxicology·Cathrine Christiansen
Sep 24, 2005·Journal of the American Society of Nephrology : JASN·Glenn M ChertowDavid W Bates
Mar 3, 2007·Critical Care : the Official Journal of the Critical Care Forum·Ravindra L MehtaUNKNOWN Acute Kidney Injury Network
Jun 23, 2009·The American Journal of Cardiology·Refat JabaraSteven V Manoukian
Dec 8, 2009·The American Journal of Cardiology·Jeremiah R Brown, Richard J Solomon
Jun 1, 2010·Scandinavian Journal of Clinical and Laboratory Investigation·Kirsten R PedersenJohan V Povlsen
Sep 3, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Frank HellerTimm H Westhoff
Aug 15, 2012·Nephron. Clinical Practice·Arif Khwaja
Oct 5, 2013·Insights Into Imaging·Remy W F GeenenAart J van der Molen
Dec 7, 2013·Scandinavian Journal of Clinical and Laboratory Investigation·Christoph LiebetrauHolger Nef
Nov 18, 2014·PloS One·Martin TepelTimm H Westhoff
Jan 9, 2016·PloS One·Jan EbbingTimm H Westhoff
Jun 9, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sushrut S WaikarUNKNOWN Chronic Kidney Disease Biomarkers Consortium Investigators
Jun 12, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jens H WesthoffTimm H Westhoff
Aug 31, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Xuexian TanYan Lin
Nov 14, 2017·The New England Journal of Medicine·Steven D WeisbordUNKNOWN PRESERVE Trial Group
Aug 6, 2018·Kidney & Blood Pressure Research·Felix S SeibertTimm H Westhoff
Oct 23, 2018·Kidney & Blood Pressure Research·Julia NeuhausTimm H Westhoff
Jan 13, 2019·Journal of Clinical Medicine·Jia-Jin ChenChih-Hsiang Chang

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Citations

Dec 5, 2020·Journal of Nephrology·Felix S SeibertTimm H Westhoff
May 29, 2021·Journal of the American College of Cardiology·Giuseppina RoscignoCarlo Briguori

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

GraphPad
SPSS Statistics
Prism

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