Biomarkers in traumatic brain injury: new concepts

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Dana SlavoacaPieter Vos

Abstract

Traumatic brain injury is a multifaceted condition that encompasses a spectrum of injuries: contusions, axonal injuries in specific brain regions, edema, and hemorrhage. Brain injury determines a broad clinical and disability spectrum due to the implication of various cellular pathways, genetic phenotypes, and environmental factors. It is challenging to predict patient outcomes, to appropriately evaluate the patients, to determine a suitable treatment strategy and rehabilitation program, and to communicate with patient relatives. Biomarkers detected from body fluids are potential evaluation tools for traumatic brain injury patients. These may serve as internal indicators of cerebral damage, delivering valuable information about the dynamic cellular, biochemical, and molecular environments. The diagnostic and prognostic value of biomarkers tested both in animal models of traumatic brain injury is still under question, despite a considerable scientific literature. Recent publications emphasize that a more realistic approach involves combining multiple types of biomarkers with other investigative tools (imaging, outcome scales, and genetic polymorphisms). Additionally, there is increasing interest in the use of biomarkers as tools...Continue Reading

References

Jan 5, 2002·Journal of Neuroimmunology·Philipp M LenzlingerMaria Cristina Morganti-Kossmann
Jan 26, 2005·The Journal of Head Trauma Rehabilitation·John T Povlishock, Douglas I Katz
Oct 25, 2006·Brain Injury : [BI]·Sharon E WattMichael R Fearnside
Nov 23, 2006·Neurology India·Aysegül BayirSaid Bodur
Oct 30, 2007·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Hiroyuki Yokota
Mar 5, 2009·Journal of Neurotrauma·Brian J BlythJeffrey J Bazarian
Apr 7, 2009·The Journal of Surgical Research·Po-Chou LiliangJiin-Haur Chuang
Mar 13, 2010·Journal of Neuroinflammation·Georgene W HergenroederPramod K Dash
Dec 21, 2011·Journal of Neurotrauma·Michèle TanguyYannick Malledant
Jan 31, 2012·Experimental Neurology·Victoria E JohnsonDouglas H Smith
Feb 11, 2012·Acta neurochirurgica·Zandra Olivecrona, Lars-Owe D Koskinen
Mar 28, 2012·Neurological Research·Ahmer AliYuchuan Ding
Mar 8, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Guo-Feng YuXiao-Feng Fan
Mar 14, 2013·PloS One·Nicola MarchiDamir Janigro

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Citations

Jan 4, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Jun ZhangLun Dong
Oct 11, 2020·Seminars in Cell & Developmental Biology·Isabell Nessel, Adina T Michael-Titus

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