Biomarkers of a five-domain translational substrate for schizophrenia and schizoaffective psychosis

Biomarker Research
Stephanie Fryar-Williams, Jörg E Strobel

Abstract

The Mental Health Biomarker Project (2010-2014) selected commercial biochemistry markers related to monoamine synthesis and metabolism and measures of visual and auditory processing performance. Within a case-control discovery design with exclusion criteria designed to produce a highly characterised sample, results from 67 independently DSM IV-R-diagnosed cases of schizophrenia and schizoaffective disorder were compared with those from 67 control participants selected from a local hospital, clinic and community catchment area. Participants underwent protocol-based diagnostic-checking, functional-rating, biological sample-collection for thirty candidate markers and sensory-processing assessment. Fifteen biomarkers were identified on ROC analysis. Using these biomarkers, odds ratios, adjusted for a case-control design, indicated that schizophrenia and schizoaffective disorder were highly associated with dichotic listening disorder, delayed visual processing, low visual span, delayed auditory speed of processing, low reverse digit span as a measure of auditory working memory and elevated levels of catecholamines. Other nutritional and biochemical biomarkers were identified as elevated hydroxyl pyrroline-2-one as a marker of oxidat...Continue Reading

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Citations

May 10, 2017·Journal of Child and Adolescent Psychopharmacology·Jessica L HamblyAlison Haywood
Aug 10, 2020·Neuroscience and Biobehavioral Reviews·Verónica Mäki-MarttunenThomas Espeseth
Apr 28, 2021·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Benjamin WarrenJulia J Rucklidge

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Methods Mentioned

BETA
urine collection
Fluorescence
PCR
blood

Software Mentioned

EsyFit
XLSTAT
MediTECH
EasyFit

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