Biomarkers of Aging in HIV-Infected Children on Suppressive Antiretroviral Therapy

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Stephanie ShiauLouise Kuhn

Abstract

Data on accelerated aging in HIV-infected children are limited. In this study, we assess 2 biomarkers of aging-telomere length and DNA methylation (DNAm) age-in a cohort of early-treated HIV-infected children and compare these aging biomarkers with HIV-exposed uninfected (HEU) and HIV-unexposed uninfected (HUU) children. Cross-sectional study of 120 HIV-infected, 33 HEU, and 25 HUU children enrolled in a cohort study in Johannesburg, South Africa. The mean age of children was 6.4 years at the time of measurement. HIV-infected children initiated ritonavir-boosted lopinavir-based antiretroviral therapy before 2 years of age and had been on continuous antiretroviral therapy until biomarker measurement. Telomere length was determined using multiplex quantitative polymerase chain reaction. DNAm was measured using the Illumina 450K array and DNAm age was calculated as the acceleration residual from regressing DNAm age on chronological age. Telomere length (ln[Kb/genome]) was shorter in HIV-infected children compared with HUU children (4.14 ± 0.85 vs. 4.53 ± 0.79, P = 0.038) and in HEU children compared with HUU children (4.05 ± 0.74 vs. 4.53 ± 0.79, P = 0.023). Age acceleration residual based on DNAm levels was not different between ...Continue Reading

References

May 20, 1998·Proceedings of the National Academy of Sciences of the United States of America·R W FrenckK M Shannon
May 10, 2002·Nucleic Acids Research·Richard M Cawthon
Sep 21, 2007·Human Molecular Genetics·Tim De MeyerUNKNOWN Asklepios investigators
Nov 21, 2008·The New England Journal of Medicine·Avy ViolariUNKNOWN CHER Study Team
Feb 24, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pablo J E J van de BergRené A W van Lier
Sep 9, 2010·JAMA : the Journal of the American Medical Association·Ashraf CoovadiaLouise Kuhn
Mar 4, 2011·Biological Procedures Online·Nathan J O'Callaghan, Michael Fenech
Oct 15, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Giovanni GuaraldiFrank Palella
May 10, 2012·BMC Bioinformatics·Eugene Andres HousemanKarl T Kelsey
May 15, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Tuhina ImamHélène C F Côté
Sep 18, 2012·Best Practice & Research. Clinical Endocrinology & Metabolism·S A S LangieJ C Mathers
Jan 15, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Yi-an ChenRosanna Weksberg
Oct 22, 2013·Genome Biology·Steve Horvath
Jan 25, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·DeAnna L ZanetHélène C F Côté
Sep 10, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Suman SrinivasaSteven K Grinspoon
Oct 17, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·José-Ramón BlancoUNKNOWN CoRIS-Biobanco
Mar 26, 2015·PloS One·Tammy M RickabaughBeth D Jamieson
May 15, 2015·The Journal of Infectious Diseases·Steve Horvath, Andrew J Levine
Nov 4, 2015·JAMA : the Journal of the American Medical Association·Ashraf CoovadiaLouise Kuhn
Mar 19, 2016·AIDS·Ketty GianesinAnita De Rossi
Jan 7, 2017·BioMed Research International·Ruheena JavedHuiying Liang
Apr 19, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Pamela M MurnaneLouise Kuhn
Aug 11, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Alejandro Gonzalez-SernaHélène C F Côté
Dec 12, 2017·The Journal of Infectious Diseases·Abhinav AjaykumarUNKNOWN CIHR Team in Cellular Aging and HIV Comorbidities in Women and Children
Apr 7, 2018·Archives of Osteoporosis·Stephanie ShiauStephen M Arpadi

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Citations

Jun 9, 2020·Journal of Immunology Research·Annalisa DalziniAnita De Rossi
Aug 9, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Abhinav AjaykumarHélène C F Côté
Mar 26, 2021·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Stephanie ShiauMichael T Yin

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