Biomarkers of airway acidity and oxidative stress in exhaled breath condensate from grain workers

American Journal of Respiratory and Critical Care Medicine
Ron DoSusan M Kennedy

Abstract

Grain workers report adverse respiratory symptoms due to exposures to grain dust and endotoxin. Studies have shown that biomarkers in exhaled breath condensate (EBC) vary with the severity of airway inflammation. The purpose of the study was to evaluate biomarkers of airway acidity (pH and ammonium [NH(4)(+)]) and oxidative stress (8-isoprostane) in the EBC of grain workers. A total of 75 workers from 5 terminal elevators participated. In addition to EBC sampling, exposure monitoring for inhalable grain dust and endotoxin was performed; spirometry, allergy testing, and a respiratory questionnaire derived from that of the American Thoracic Society were administered. Dust and endotoxin levels ranged from 0.010 to 13 mg/m(3) (median, 1.0) and 8.1 to 11,000 endotoxin units/m(3) (median, 610) respectively. EBC pH values varied from 4.3 to 8.2 (median, 7.9); NH(4)(+) values from 22 to 2,400 microM (median, 420); and 8-isoprostane values from 1.3 to 45 pg/ml (median, 11). Univariate and multivariable analyses revealed a consistent effect of cumulative smoking and obesity with decreased pH and NH(4)(+), and intensity of grain dust and endotoxin with increased 8-isoprostane. Duration of work on the test day was associated with decreased...Continue Reading

References

Apr 1, 1979·Chest·M Chan-YeungL MacLean
Nov 15, 1992·American Journal of Epidemiology·M Chan-YeungS M Kennedy
Dec 1, 1991·The American Review of Respiratory Disease·T HuyS M Kennedy
Sep 1, 1990·The American Journal of Medicine·H E Mattox, J E Richter
May 1, 1986·Infection and Immunity·D L Peavy, E J Fairchild
Sep 1, 1983·The American Review of Respiratory Disease·G A doPicoE Smalley
Aug 1, 1995·American Journal of Respiratory and Critical Care Medicine·S A KharitonovP J Barnes
Aug 1, 1995·American Journal of Respiratory and Critical Care Medicine·D A SchwartzT J Quinn
Nov 1, 1994·The American Journal of Physiology·D A SchwartzK L Frees
Jul 1, 1994·American Journal of Respiratory and Critical Care Medicine·S M KennedyM Chan-Yeung
Jan 1, 1997·American Journal of Respiratory and Critical Care Medicine·D C DeetzD A Schwartz
Nov 14, 1997·American Journal of Respiratory and Critical Care Medicine·O MichelR Sergysels
Nov 7, 1998·American Journal of Respiratory Cell and Molecular Biology·Y SuE R Block
May 14, 1999·British Journal of Pharmacology·K AnderssonP Arner
Jun 3, 1999·American Journal of Respiratory and Critical Care Medicine·S A ComhairS C Erzurum
Jun 23, 1999·The American Journal of Medicine·G R LockeL J Melton
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·P MontuschiP J Barnes
Mar 11, 2000·American Journal of Respiratory and Critical Care Medicine·J F HuntB Gaston
Oct 13, 2000·American Journal of Respiratory and Critical Care Medicine·H D Held, S Uhlig
Jan 10, 2002·American Journal of Respiratory and Critical Care Medicine·John F HuntBenjamin Gaston
May 23, 2002·American Journal of Respiratory and Critical Care Medicine·Konstantinos KostikasStelios Loukides
Jul 3, 2003·JAMA : the Journal of the American Medical Association·Magnus NilssonJesper Lagergren
Jul 11, 2003·Chest·Eugenio BaraldiPaolo Montuschi
Aug 13, 2003·International Journal of Epidemiology·Liam MurrayRichard Harvey
Aug 21, 2003·The American Journal of Medicine·Richard M EffrosJulie Biller
Apr 22, 2004·The Journal of Allergy and Clinical Immunology·Fabio L M RicciardoloJohn Hunt
Feb 3, 2005·The European Respiratory Journal·Z BorrillD Singh
Mar 3, 2005·Lung·Amelia W NgThomas A Heming
May 4, 2005·The Journal of Allergy and Clinical Immunology·Stephanie A Shore, Jeffrey J Fredberg
Jan 6, 2006·Journal of Environmental Monitoring : JEM·Suzanne SpaanDick Heederik
Feb 16, 2006·Journal of Internal Medicine·G E CarpagnanoM P Foschino-Barbaro
Feb 16, 2006·Current Allergy and Asthma Reports·John Hunt
Feb 16, 2006·Chest·Alix O Paget-BrownJohn F Hunt
Feb 28, 2006·European Journal of Pharmacology·Irfan RahmanAruna Kode
Apr 4, 2006·Environmental Health Perspectives·Andrea CaglieriAntonio Mutti
Apr 12, 2006·Journal of Occupational and Environmental Medicine·Paul D BoyceDavid C Christiani
Sep 18, 2007·American Journal of Respiratory and Critical Care Medicine·Nicole Le MoualSusan M Kennedy

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Citations

Nov 19, 2009·International Archives of Occupational and Environmental Health·Davor RimacIvan Pavicić
Sep 26, 2012·International Archives of Occupational and Environmental Health·Anita Ljubičić ĆalušićJelena Macan
Jun 29, 2012·International Archives of Allergy and Immunology·X MuñozM J Cruz
Jun 6, 2009·American Journal of Respiratory and Critical Care Medicine·Richard M Effros
Dec 15, 2010·International Journal of Molecular Sciences·Monika JanickaJacek Namieśnik
Nov 6, 2013·Journal of Chromatographic Science·Masha PitiranggonBeizhan Yan
Dec 7, 2010·Experimental Lung Research·Anita Ljubičić CalušićJelena Macan
May 29, 2012·Free Radical Biology & Medicine·Wanxing Eugene HoW S Fred Wong
Apr 14, 2010·Equine Veterinary Journal·A G WhittakerK J Hughes
Dec 10, 2009·Current Opinion in Allergy and Clinical Immunology·Massimo CorradiAntonio Mutti
Jul 22, 2014·Journal of Occupational and Environmental Medicine·Anita LjubičićJelena Macan
Jun 3, 2020·International Journal of Molecular Sciences·Yara ShomanIrina Guseva Canu
Dec 4, 2019·Current Opinion in Allergy and Clinical Immunology·Piero MaestrelliGabriella Guarnieri
Aug 21, 2020·International Journal of Occupational Safety and Ergonomics : JOSE·Vahid GharibiMajid Bagheri Hosseinabadi
Nov 8, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Toby K McGovernMikael Adner
Dec 23, 2009·Current Opinion in Allergy and Clinical Immunology
Apr 2, 2010·Current Opinion in Allergy and Clinical Immunology

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