Biomarkers of appetite: is there a potential role for metabolomics?

Nutrition Research Reviews
Katy HornerLorraine Brennan

Abstract

Knowing the biological signals associated with appetite control is crucial for understanding the regulation of food intake. Biomarkers of appetite have been defined as physiological measures that relate to subjective appetite ratings, measured food intake, or both. Several metabolites including amino acids, lipids and glucose were proposed as key molecules associated with appetite control over 60 years ago, and along with bile acids are all among possible appetite biomarker candidates. Additional metabolites that have been associated with appetite include endocannabinoids, lactate, cortisol and β-hydroxybutyrate. However, although appetite is a complex integrative process, studies often investigated a limited number of markers in isolation. Metabolomics involves the study of small molecules or metabolites present in biological samples such as urine or blood, and may present a powerful approach to further the understanding of appetite control. Using multiple analytical techniques allows the characterisation of molecules, such as carbohydrates, lipids, amino acids, bile acids and fatty acids. Metabolomics has proven successful in identifying markers of consumption of certain foods and biomarkers implicated in several diseases. Ho...Continue Reading

References

Jun 1, 1991·Physiology & Behavior·C Erlanson-AlbertssonG A Bray
Apr 1, 1991·Trends in Pharmacological Sciences·J Blundell
Dec 1, 1989·Appetite·C P Sepple, N W Read
Dec 1, 1988·The American Journal of Physiology·K AraseG A Bray
Jul 1, 1985·Journal of the Autonomic Nervous System·W LanghansE Scharrer
May 18, 1968·Lancet·G A Bray, T F Gallagher
Oct 1, 1994·The American Journal of Clinical Nutrition·A RabenA Astrup
Jan 1, 1996·Neuroscience and Biobehavioral Reviews·L A CampfieldJ Hirsch
Aug 1, 1996·The American Journal of Physiology·J H LavinN W Read
Nov 1, 1996·Diabetes·J F CaroR V Considine
Jul 1, 1997·Metabolism: Clinical and Experimental·T M WoleverJ L Chiasson
Mar 21, 1998·Metabolism: Clinical and Experimental·H A GielkensA A Masclee
Aug 13, 1999·The American Journal of Physiology·K J MelansonL A Campfield
May 23, 2000·Annals of Medicine·J C Halford, J E Blundell
Oct 26, 2002·The American Journal of Clinical Nutrition·G Harvey AndersonThomas M S Wolever
Dec 31, 2002·Physiological Reviews·L Arthur Campfield, Françoise J Smith
Mar 12, 2003·The Journal of Clinical Endocrinology and Metabolism·Bernd SchultesAchim Peters
Mar 14, 2003·Public Health Nutrition·Victor KipnisRaymond J Carroll
Mar 18, 2003·Public Health Nutrition·Sheila A Bingham
Jul 2, 1953·The New England Journal of Medicine·J MAYER
Mar 1, 1956·Journal of Applied Physiology·S M MELLINKOFFM GREIPEL
May 1, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J GlatzleH E Raybould
May 26, 2004·The American Journal of Clinical Nutrition·Cees de GraafHenk F J Hendriks
Dec 29, 2004·Physiology & Behavior·Patrick Tso, Min Liu
Mar 22, 2005·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·T C M Adam, M S Westerterp-Plantenga
Aug 26, 2006·Obesity·John E Blundell
Dec 13, 2006·The American Journal of Clinical Nutrition·Anne FlintArne Astrup
May 15, 2007·European Journal of Nutrition·Johannes ErdmannVolker Schusdziarra
May 15, 2007·Gastroenterology·A M Wren, S R Bloom
Mar 18, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·K DiepvensM Westerterp-Plantenga
Apr 25, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jin FuDaniele Piomelli
Jun 7, 2008·Regulatory Peptides·J E BlundellE Naslund
Jun 26, 2008·American Journal of Physiology. Endocrinology and Metabolism·Carol K L LamTony K T Lam

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nursing Older People
Anna L PilgrimHelen C Roberts
Proceedings of the National Academy of Sciences of the United States of America
Vincenzo Di Marzo
Current Drug Targets
Jason C G HalfordTerence M Dovey
© 2021 Meta ULC. All rights reserved