Biomarkers of Brain Damage Induced by Radiotherapy

Dose-response : a Publication of International Hormesis Society
Nahida SultanaBing Wang

Abstract

Radiotherapy remains currently a critical component for both primary and metastatic brain tumors either alone or in combination with surgery, chemotherapy, and molecularly targeted agents, while it could cause simultaneously normal brain tissue injury leading to serious health consequences, that is, development of cognitive impairments following cranial radiotherapy is considered as a critical clinical disadvantage especially for the whole brain radiotherapy. Biomarkers can help to detect the accurate physiology or conditions of patients with brain tumor and develop effective treatment procedures for these patients. In the near future, biomarkers will become one of the prime driving forces of cancer treatment. In this minireview, we analyze the documented work on the acute brain damage and late consequences induced by radiotherapy, identify the biomarkers, in particular, the predictive biomarkers for the damage, and summarize the biological significance of the biomarkers. It is expected that translation of these research advance to radiotherapy would assist stratifying patients for optimized treatment and improving therapeutic efficacy and the quality of life.

References

Sep 1, 1992·The British Journal of Radiology·T E Schultheiss, L C Stephens
Jan 1, 1990·International Journal of Radiation Oncology, Biology, Physics·H S ReinholdA P van der Berg
Jan 1, 1980·International Journal of Radiation Oncology, Biology, Physics·B BorgeltF R Hendrickson
Sep 1, 1980·International Journal of Radiation Oncology, Biology, Physics·G E ShelineV Smith
Jun 1, 1980·Annals of Neurology·J G CairncrossJ B Posner
Oct 15, 1995·International Journal of Radiation Oncology, Biology, Physics·T UseniusR Kauppinen
Jun 11, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P J Basser, C Pierpaoli
Mar 31, 1999·International Journal of Radiation Oncology, Biology, Physics·F J LagerwaardP I Schmitz
Apr 28, 1999·Journal of Neuropathology and Experimental Neurology·K H Plate
May 8, 2000·Radiation Research·P J Tofilon, J R Fike
Mar 10, 2001·Clinical Pharmacology and Therapeutics·UNKNOWN Biomarkers Definitions Working Group.
Apr 5, 2001·British Journal of Cancer·W JacotUNKNOWN Association d'Enseignement et de Recherche des Internes en Oncologie
Sep 25, 2001·International Journal of Radiation Oncology, Biology, Physics·S N SanghaviM P Mehta
Nov 27, 2001·British Journal of Cancer·C BelkaM Bamberg
Nov 28, 2001·Current Opinion in Neurology·P New
Mar 28, 2002·Seminars in Radiation Oncology·Yuhchyau ChenPaul Okunieff
Jun 14, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·James W Denham, Martin Hauer-Jensen
Nov 5, 2002·European Journal of Radiology·V F H ChongH Rumpel
Dec 26, 2002·Neurological Research·Toshiyuki AmanoKiyonobu Ikezaki
Jan 24, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·F A HoweJ R Griffiths
Feb 18, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·C FoerchM Sitzer
Apr 12, 2003·Technology in Cancer Research & Treatment·Roy A Patchell, William F Regine
Jun 5, 2003·Nature Medicine·Napoleone FerraraJennifer LeCouter
Sep 11, 2003·The Lancet Oncology·Helen B StoneWilliam H McBride
Dec 4, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Tom B JohannesenKnut Lote
Apr 6, 2004·Journal of Magnetic Resonance Imaging : JMRI·Michael C LeeSarah J Nelson
Oct 9, 2004·Molecular Interventions·C Shun Wong, Albert J Van der Kogel
Jan 8, 2005·Seminars in Neurology·Anthony Béhin, Jean-Yves Delattre
Jan 25, 2005·Cardiovascular Research·Tuomas TammelaKarri Paavonen
Jun 23, 2005·Cancer·Michael A VogelbaumDamir Janigro
Dec 6, 2005·Nature Cell Biology·Ali JazayeriStephen P Jackson
Mar 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christina A Meyers, Paul D Brown

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Citations

Nov 3, 2020·Frontiers in Oncology·Elvira V Grigorieva

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Methods Mentioned

BETA
X-ray
imaging technique
imaging techniques
chromosomal
flow cytometry

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