Abstract
The validation of effective screening tools for the identification of patients with subclinical myocardial remodelling is a major clinical need. Thus, we explored the associations of circulating biomarkers of cardiomyocyte injury and stress with subclinical cardiac remodelling and dysfunction, and with biomarkers reflecting collagen turnover. We randomly recruited 727 subjects from a general population (51.2% women; mean age 51.3 years). Measurements included echocardiographic left atrial (LA) and left ventricular (LV) structure and function, quantification of high sensitivity cardiac Troponin T (hs-cTnT), NT-proBNP, and biomarkers of collagen types I and III turnover. In unadjusted and adjusted analyses, the prevalence of LA enlargement (LAE), LV hypertrophy (LVH) and LV diastolic dysfunction (LVDD) increased with higher hs-cTnT (P ≤ 0.031). NT-proBNP was independently associated with LVDD (P=0.009). Both biomarkers combined yielded significant integrated discrimination and net reclassification improvements (P ≤ 0.014 and P ≤ 0.009, respectively) for LAE, LVH and LVDD, over the conventional risk factors, and were independently and positively associated with biomarkers of collagen type I turnover. In a sensitivity analysis, aft...Continue Reading
References
Jun 1, 1991·Circulation·K T Weber, C G Brilla
Aug 3, 2002·Hypertension·M Mitchell LindsayFrancis G Dunn
Jan 9, 2003·JAMA : the Journal of the American Medical Association·Margaret M RedfieldRichard J Rodeheffer
Oct 3, 2003·Journal of the American College of Cardiology·Teresa S M TsangJames B Seward
Sep 29, 2004·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·John S GottdienerUNKNOWN American Society of Echocardiography
Nov 20, 2004·Current Problems in Cardiology·Vijaya K MunagalaMargaret M Redfield
Jul 9, 2008·European Heart Journal·Kai M EggersBertil Lindahl
Oct 8, 2009·Circulation. Heart Failure·Tatiana KuznetsovaJan A Staessen
Jan 12, 2010·Circulation. Cardiovascular Imaging·Michel G KhouriMark H Drazner
Feb 9, 2010·Expert Review of Cardiovascular Therapy·Tatiana KuznetsovaJan A Staessen
Apr 14, 2010·Circulation·Begoña LópezJavier Díez
Apr 21, 2010·Hypertension·Arantxa GonzálezJavier Díez
May 19, 2010·European Journal of Preventive Cardiology·Dimitrios N TziakasStavros Konstantinides
Jul 28, 2010·American Journal of Epidemiology·Tatiana KuznetsovaNilesh J Samani
Dec 9, 2010·JAMA : the Journal of the American Medical Association·James A de LemosDarren K McGuire
Jan 5, 2011·Statistics in Medicine·Michael J PencinaEwout W Steyerberg
Mar 23, 2011·Circulation·Justin T SaundersChristie M Ballantyne
Aug 2, 2011·Mayo Clinic Proceedings·Dharmendrakumar A PatelHector O Ventura
Oct 14, 2011·Blood Pressure·Cesare CuspidiGiuseppe Mancia
Nov 23, 2011·The Canadian Journal of Cardiology·Simon de DenusMichel White
Mar 21, 2012·Cardiovascular Ultrasound·Malgorzata Kloch-BadelekUNKNOWN European Project On Genes in Hypertension (EPOGH) Investigators
Jun 12, 2012·Circulation. Heart Failure·Willem J KopRobert H Christenson
Jul 12, 2012·European Heart Journal·Sachin GuptaMark H Drazner
Aug 10, 2012·American Journal of Epidemiology·Nancy R Cook
Aug 28, 2012·Journal of the American College of Cardiology·M Adnan NadirAllan D Struthers
Dec 12, 2012·Journal of Internal Medicine·S MassonUNKNOWN PREDICTOR study
Dec 12, 2012·Journal of the American College of Cardiology·Ian J NeelandJames A de Lemos
May 2, 2014·Journal of the American Heart Association·Tatiana KuznetsovaJan A Staessen
Citations
Feb 2, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Anna M NordenskjöldBertil Lindahl
Jun 21, 2017·Proceedings of the National Academy of Sciences of the United States of America·Xiaoyang LiHongjie Dai
Feb 22, 2018·Medical Sciences : Open Access Journal·Tom Kai Ming WangGladding Patrick
Sep 11, 2018·European Journal of Preventive Cardiology·Zhen-Yu ZhangJan A Staessen
Jun 28, 2017·BMJ Open·Wenkai XiaoPing Ye
Sep 20, 2017·Current Medicinal Chemistry·Polychronis DilaverisDimitris Tousoulis
Mar 31, 2019·American Journal of Epidemiology·Annemarie WentzelNicolaas T Malan
Jul 4, 2020·Journal of Hypertension·Gernot PichlerAlicia Maceira
Apr 9, 2017·The International Journal of Cardiovascular Imaging·Tom HendriksPim van der Harst
Jun 29, 2017·Annals of Clinical Biochemistry·Michèle NataleIbrahim Akin
May 26, 2018·Transplantation Direct·Qi-Fang HuangJan A Staessen
Nov 11, 2018·Translational Stroke Research·Annemarie WentzelNicolaas T Malan
Jan 15, 2019·Journal of the American Heart Association·Nicholas CauwenberghsTatiana Kuznetsova
May 20, 2020·JRSM Cardiovascular Disease·Mariya KukSanjay K Prasad
Sep 6, 2020·Journal of Hypertension·Gernot PichlerAlicia Maceira
Oct 31, 2020·BMC Medicine·Sharon RemmelzwaalJoline W J Beulens
Nov 1, 2020·Archivos de bronconeumología·Raúl GaleraFrancisco García-Río
Jun 6, 2021·Archivos de bronconeumología·Raúl GaleraFrancisco García-Río