Biomarkers of Chondrocyte Apoptosis and Autophagy in Osteoarthritis

International Journal of Molecular Sciences
Giuseppe MusumeciAli Mobasheri

Abstract

Cell death with morphological and molecular features of apoptosis has been detected in osteoarthritic (OA) cartilage, which suggests a key role for chondrocyte death/survival in the pathogenesis of OA. Identification of biomarkers of chondrocyte apoptosis may facilitate the development of novel therapies that may eliminate the cause or, at least, slow down the degenerative processes in OA. The aim of this review was to explore the molecular markers and signals that induce chondrocyte apoptosis in OA. A literature search was conducted in PubMed, Scopus, Web of Science and Google Scholar using the keywords chondrocyte death, apoptosis, osteoarthritis, autophagy and biomarker. Several molecules considered to be markers of chondrocyte apoptosis will be discussed in this brief review. Molecular markers and signalling pathways associated with chondroycte apoptosis may turn out to be therapeutic targets in OA and approaches aimed at neutralizing apoptosis-inducing molecules may at least delay the progression of cartilage degeneration in OA.

References

Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·S HashimotoM Lotz
May 4, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·R ItayemF P Reinholt
Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K KühnM Lotz
Jun 20, 2001·Nature Reviews. Molecular Cell Biology·M J BerridgeM D Bootman
Jul 24, 2001·Arthritis and Rheumatism·K Kühn, M Lotz
Feb 13, 2002·Arthritis and Rheumatism·Marcello Del Carlo, Richard F Loeser
Jan 15, 2005·Annals of the New York Academy of Sciences·Simone Fulda, Klaus-Michael Debatin
Feb 15, 2005·Annals of the Rheumatic Diseases·E ManeiroF J Blanco
May 14, 2005·CA: a Cancer Journal for Clinicians·Irene M GhobrialAlex A Adjei
Apr 4, 2007·Annals of the New York Academy of Sciences·Mehdi ShakibaeiAli Mobasheri
Nov 22, 2007·Aging Cell·Béatrice ChabiDavid A Hood
Dec 26, 2007·The Journal of Experimental Medicine·Shigeyuki KonToshimitsu Uede
Apr 14, 2009·Clinical Orthopaedics and Related Research·Alexis C Dang, Hubert T Kim
Aug 18, 2009·Nature Medicine·Frank EchtermeyerThomas Pap
Jan 22, 2010·Apoptosis : an International Journal on Programmed Cell Death·M Almonte-BecerrilJ B Kouri
Jul 21, 2010·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Giuseppe MusumeciGiuseppa Martinez
Jul 31, 2010·International Journal of Clinical Rheumatology·Shawn P Grogan, Darryl D D'Lima
Feb 18, 2011·Osteoarthritis and Cartilage·W B van den Berg
Apr 27, 2011·International Journal of Rheumatic Diseases·Zaitunnatakhin Zamli, Mohammed Sharif
Aug 3, 2011·Nature Reviews. Rheumatology·Martin K Lotz, Beatriz Caramés
Aug 6, 2011·International Journal of Rheumatic Diseases·Carla M ThomasMohammed Sharif
Jan 3, 2012·Acta histochemica·Rosalia LeonardiGiuseppe Musumeci
Jan 17, 2012·Archives of Oral Biology·Rosalia LeonardiCarla Loreto

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Citations

Dec 31, 2016·International Journal of Molecular Sciences·Pu-Rong ChiuKee-Lung Chang
Feb 6, 2017·BMC Complementary and Alternative Medicine·In-Chi YoungFeng-Huei Lin
Jul 1, 2017·Annals of the New York Academy of Sciences·Andrey S MarchevMilen I Georgiev
Jul 20, 2017·Journal of Cellular Physiology·Zhen CaoShiwu Dong
Jun 13, 2018·Journal of Cellular Biochemistry·Zhongmeng YangQing Zhao
Dec 18, 2019·The Journal of International Medical Research·Jun ZhangTao Li
Dec 19, 2019·Expert Review of Molecular Diagnostics·Anne Christine Bay-JensenMorten Asser Karsdal
Feb 13, 2018·Experimental and Therapeutic Medicine·Huihui LiWeiguo Xu
Sep 5, 2020·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Paola CastrogiovanniGiuseppe Musumeci
Jul 11, 2018·Frontiers in Physiology·Claire VinatierBeatriz Caramés
Jan 30, 2019·International Journal of Molecular Sciences·Paola CastrogiovanniGiuseppe Musumeci
Aug 30, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Yan ZhouShiqing Liu
Sep 2, 2017·BMC Musculoskeletal Disorders·Xinxin WangXiang Gao
Feb 3, 2018·Molecular Medicine Reports·Ling-Rui ZhaoLi Zhang
Nov 28, 2018·World Journal of Orthopedics·Silvia RavalliGiuseppe Musumeci
Apr 5, 2019·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Yibin LiuAunhua Jin
Sep 17, 2019·International Journal of Molecular Medicine·Shangzeng WangLicheng Wei
Aug 4, 2019·International Journal of Molecular Sciences·Consuelo AriasLuis A Salazar
Apr 25, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Jiahua ShaoYi Chen
Sep 22, 2020·Inflammation·Swati ChadhaDeepak Chandel
Jan 4, 2019·Tissue Engineering and Regenerative Medicine·Jaeseong ParkTong In Oh

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Methods Mentioned

BETA
enzyme
fluorescence activated cell sorter
electron microscopy
ELISA

Software Mentioned

Web
Google Scholar
Scopus

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