Biomarkers of Delirium in a Low-Risk Community-Acquired Pneumonia-Induced Sepsis

Molecular Neurobiology
Cristiane Damiani TomasiFelipe Dal-Pizzol

Abstract

There are different theories about the pathophysiology of sepsis-associated encephalopathy (SAE), and the majority of our knowledge was derived from critically ill patients. 7In less severe sepsis, it is probable that neuroinflammation can be a major aspect of SAE development. We hypothesized that in non-severe septic patients, blood biomarkers of inflammation, endothelial activation, coagulation, and brain function would be different when compared to patients with and without brain dysfunction. A total of 30 patients presenting with community-acquired pneumonia (CAP)-induced sepsis were included of which 10 (33 %) developed SAE. Eight medical patients admitted to the general ward, except due to sepsis or infection, which developed delirium were included as delirium, non-sepsis group. From all measured biomarkers, only brain-derived neurotrophic factor (BDNF), regulated upon activation normal T cell expressed, and presumably secreted (RANTES), and interleukin (IL)-10 where significantly different when compared to SAE and sepsis groups. In addition, SAE patients presented higher levels of BDNF, vascular cellular adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), platelet-derived growth factor (PDGF)-AB/BB ...Continue Reading

References

Dec 15, 1990·Annals of Internal Medicine·S K InouyeR I Horwitz
Mar 29, 2003·Intensive Care Medicine·Mitchell M LevyUNKNOWN International Sepsis Definitions Conference
Jul 26, 2007·British Journal of Anaesthesia·O PiazzaR Tufano
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Oct 19, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ronan M G BergKirsten Møller
Dec 19, 2012·Critical Care : the Official Journal of the Critical Care Forum·Cristiane RitterFelipe Dal-Pizzol
Dec 25, 2012·Anesthesiology·Christopher G HughesPratik P Pandharipande
May 31, 2013·Annals of Intensive Care·Romain SonnevilleTarek Sharshar
Jul 16, 2013·American Journal of Respiratory and Critical Care Medicine·Faraaz Ali ShahSachin Yende
Jun 3, 2014·Critical Care : the Official Journal of the Critical Care Forum·Cristiane RitterMervyn Singer

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Citations

May 28, 2016·Molecular Neurobiology·Bernardo Bollen PintoMervyn Singer
Mar 12, 2019·Journal of Geriatric Psychiatry and Neurology·Monique MichelsFelipe Dal-Pizzol
Aug 19, 2020·Expert Review of Anti-infective Therapy·Simone C TauberRoland Nau
Jan 27, 2021·Molecular Neurobiology·Diogo DominguiniFelipe Dal-Pizzol
Jul 1, 2021·Journal of Proteome Research·Guangju GeGonghui Li

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Methods Mentioned

BETA
ELISA

Software Mentioned

SPSS

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