Biomarkers of endocannabinoid system activation in severe obesity.

PloS One
J C SipeJ Waalen

Abstract

Obesity is a worldwide epidemic, and severe obesity is a risk factor for many diseases, including diabetes, heart disease, stroke, and some cancers. Endocannabinoid system (ECS) signaling in the brain and peripheral tissues is activated in obesity and plays a role in the regulation of body weight. The main research question here was whether quantitative measurement of plasma endocannabinoids, anandamide, and related N-acylethanolamines (NAEs), combined with genotyping for mutations in fatty acid amide hydrolase (FAAH) would identify circulating biomarkers of ECS activation in severe obesity. Plasma samples were obtained from 96 severely obese subjects with body mass index (BMI) of > or = 40 kg/m(2), and 48 normal weight subjects with BMI of < or = 26 kg/m(2). Triple-quadrupole mass spectroscopy methods were used to measure plasma ECS analogs. Subjects were genotyped for human FAAH gene mutations. The principal analysis focused on the FAAH 385 C-->A (P129T) mutation by comparing plasma ECS metabolite levels in the FAAH 385 minor A allele carriers versus wild-type C/C carriers in both groups. The main finding was significantly elevated mean plasma levels of anandamide (15.1+/-1.4 pmol/ml) and related NAEs in study subjects that c...Continue Reading

References

Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·W A Devane, J Axelrod
Jan 9, 1999·Trends in Neurosciences·V Di MarzoL De Petrocellis
Feb 12, 1999·Neurobiology of Disease·V Di Marzo, D G Deutsch
Aug 26, 1999·Life Sciences·B R MartinR K Razdan
Nov 27, 1999·Forschende Komplementärmedizin·R Mechoulam
Mar 30, 2001·European Journal of Biochemistry·T BisognoV Di Marzo
Dec 31, 2002·Chemistry and Physics of Lipids·J Michael WalkerSusan M Huang
Aug 28, 2003·Current Opinion in Chemical Biology·Benjamin F Cravatt, Aron H Lichtman
Nov 20, 2004·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Fernando Rodríguez de FonsecaMiguel Navarro
Mar 17, 2005·Cellular and Molecular Life Sciences : CMLS·J Lo VermeD Piomelli
Apr 6, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J C SipeE Beutler
Apr 21, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Palmiero MonteleoneVincenzo Di Marzo
May 3, 2005·The Journal of Clinical Investigation·Douglas Osei-HyiamanGeorge Kunos
Sep 9, 2005·Behavioural Pharmacology·T C Kirkham
Sep 28, 2005·Diabetes·Stefan EngeliJens Jordan
Jan 6, 2006·Histochemistry and Cell Biology·Régis RocheFranck Festy
May 11, 2006·The Journal of Clinical Endocrinology and Metabolism·Isabel MatiasVincenzo Di Marzo
Jan 9, 2007·Clinical Cornerstone·Stefan Engeli, Jens Jordan
Jan 12, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Dorit P JensenOluf Pedersen
Jan 17, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M CôtéV Di Marzo
Apr 12, 2007·Obesity·Marie-Paule GonthierRégis Roche
Apr 9, 2008·Psychoneuroendocrinology·Ines KaufmannManfred Thiel
May 9, 2008·Journal of Neuroendocrinology·S Engeli
Jul 8, 2008·Journal of Neuroendocrinology·L BellocchioU Pagotto
Jul 9, 2008·Current Opinion in Lipidology·David Jesudason, Gary Wittert
Aug 13, 2008·The Journal of Biological Chemistry·George KunosSándor Bátkai
Sep 27, 2008·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·D PapazoglouE Maltezos
Jun 19, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Joe PalandraTimothy G Heath

❮ Previous
Next ❯

Citations

Aug 29, 2013·BioMed Research International·Elisabetta MurruGianfranca Carta
May 14, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Robert H PietrzakAlexander Neumeister
Oct 27, 2010·PLoS Computational Biology·Gaurav BhatiaVineet Bafna
Nov 30, 2013·Biology of Mood & Anxiety Disorders·Matthew N Hill, Sachin Patel
Feb 1, 2011·Nutrition & Metabolism·Sebastiano BanniMikko Griinari
Dec 12, 2013·Trends in Pharmacological Sciences·Ozge Gunduz-CinarAndrew Holmes
Feb 18, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M F BennetzenS B Pedersen
Feb 1, 2014·Expert Opinion on Therapeutic Targets·Efthymia A Katsareli, George V Dedoussis
Aug 6, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Diana JędrzejukNatalia Słoka
Sep 17, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·B Gatta-Cherifi, D Cota
Oct 1, 2015·Genes, Brain, and Behavior·T T-Y LeeF S Lee
Aug 6, 2011·Trends in Molecular Medicine·Carmelo QuartaUberto Pagotto
Apr 2, 2016·BioMed Research International·Monika HeisigJacek C Szepietowski
Jun 4, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Isabelle BoileauJunchao Tong
Jun 13, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Maria MorenaMatthew N Hill
Sep 26, 2014·Metabolomics : Official Journal of the Metabolomic Society·B VaitheesvaranJ E Bruce
Apr 12, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M I Vazquez-RoqueA R Zinsmeister
Nov 13, 2013·Drug Testing and Analysis·Natalia BattistaMauro Maccarrone
May 23, 2014·Pharmacology & Therapeutics·Chen Li, Deling Kong
Sep 29, 2015·Trends in Endocrinology and Metabolism : TEM·Wilfrid MazierDaniela Cota
Mar 19, 2015·Analytical and Bioanalytical Chemistry·Mesut BilginAndrej Shevchenko
Mar 4, 2015·Nature Communications·Iva DinchevaFrancis S Lee
Mar 2, 2017·European Journal of Endocrinology·Vincent Simon, Daniela Cota
Jun 28, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Cecilia J Hillard
Jan 24, 2020·The Journal of Clinical Endocrinology and Metabolism·Erin C HanlonEve Van Cauter
Nov 28, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Esmaeil MansouriIsabelle Boileau
Oct 7, 2018·European Archives of Psychiatry and Clinical Neuroscience·Anne GärtnerBurkhard Brocke
Jul 26, 2019·BioMed Research International·Jing WangDa Li
Sep 2, 2017·Cannabis and Cannabinoid Research·Roberto AngeliniNicholas V DiPatrizio

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Methods Mentioned

BETA
genotyping

Clinical Trials Mentioned

NCT00263042

Software Mentioned

CRESCENDO
Sequenom

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