Biomarkers of exposure, effect, and susceptibility in workers exposed to nitrotoluenes

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Gabriele SabbioniYu-Ying Liu

Abstract

Nitrotoluenes, such as 2-nitrotoluene, 2,4-dinitrotoluene (24DNT), and 26DNT, are carcinogenic in animal experiments. Humans are exposed to such chemicals in the workplace and in the environment. It is therefore important to develop methods to biomonitor people exposed to nitrotoluenes to prevent the potential harmful effects. For the present study, workers exposed to high levels of these chemicals were investigated. The external dose (air levels), the internal dose (urine metabolites), the biologically effective dose [hemoglobin (Hb) adducts and urine mutagenicity], and biological effects (chromosomal aberrations and health effects) were determined. Individual susceptibility was assessed by determining genetic polymorphisms of enzymes assumed to function in nitrotoluene metabolism, namely glutathione S-transferases (GSTM1, GSTT1, GSTP1), N-acetyltransferases (NAT1, NAT2), and sulfotransferases (SULT1A1, SULT1A2). The levels of urinary metabolites did not correlate with the air levels. The urinary mutagenicity levels determined in a subset of workers correlated with the levels of a benzylalcohol metabolite of DNT. The Hb-adducts correlated with the urine metabolites but not with the air levels. The frequency of chromosomal aber...Continue Reading

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Citations

Mar 25, 2011·Environmental Health and Preventive Medicine·Chigusa WatanabeMariko Murata
Nov 16, 2010·BMC Systems Biology·Youping DengEdward J Perkins
Jul 29, 2010·Critical Reviews in Toxicology·Gary GinsbergBabasaheb Sonawane
Sep 14, 2007·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Gabriele Sabbioni, Richard Rumler
Apr 19, 2007·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·G SabbioniY Y Liu
Dec 19, 2006·International Journal of Hygiene and Environmental Health·William W Au
Jun 14, 2012·American Journal of Industrial Medicine·Vincent BonneterreMarc Colonna
Apr 29, 2016·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Gabriele SabbioniOvnair Sepai
Sep 11, 1998·The American Journal of Gastroenterology·G A PaspatisD G Karamanolis
Apr 1, 2014·Food Chemistry·Bárbara Pelicioli RiboldiJúlia Dubois Moreira
Feb 14, 2008·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Steven R Myers, M Yeakub Ali
Nov 4, 2020·Occupational and Environmental Medicine·Chieh-Ming WuOlorunfemi Adetona
Sep 22, 2017·Chemical Research in Toxicology·Gabriele Sabbioni
Jul 17, 2020·Chemical Research in Toxicology·Gabriele SabbioniBilly W Day

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