Biomarkers of intravenous immunoglobulin resistance and coronary artery lesions in Kawasaki disease

World Journal of Pediatrics : WJP
Wei-Xing KongFangqi Gong

Abstract

Currently, there are no reliable indicators for predicting intravenous immunoglobulin resistance and coronary artery lesions in the early stage of Kawasaki disease. A total of 300 patients with Kawasaki disease were studied retrospectively. Laboratory data were compared between the intravenous immunoglobulin resistant (29 patients) and responsive groups, and between the groups with coronary artery lesions (48 patients) and without coronary artery lesions. The intravenous immunoglobulin resistant group had significantly higher D-dimer, globulin, interleukin-6 and serum ferritin levels in comparison to the intravenous immunoglobulin responder group. D-dimer level had a sensitivity of 87.0% and a specificity of 56.3% for predicting intravenous immunoglobulin resistance at a cutoff point of 1.09 mg/L. Globulin had a sensitivity of 62.1% and a specificity of 82.3% for predicting intravenous immunoglobulin resistance at a cutoff point of 34.7 g/L. Serum ferritin level had a sensitivity of 42.9% and a specificity of 88.8% for predicting intravenous immunoglobulin resistance at a cutoff point of 269.7 ng/mL. The patients with coronary artery lesions had higher D-dimer and tumor necrosis factor-α level. D-dimer level had a sensitivity o...Continue Reading

References

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Citations

Apr 23, 2020·Frontiers in Pediatrics·Yoshihiro AzumaShunji Hasegawa
May 18, 2020·World Journal of Pediatrics : WJP·Seung Beom Han, Soo-Young Lee
Apr 2, 2020·World Journal of Pediatrics : WJP·Shu WuJun-Bao Du
Mar 12, 2021·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Shuran ShaoChuan Wang
Jan 28, 2022·Biomarkers in Medicine·Sergio Huerta Barberá, Antonio Sánchez Andrés

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