May 19, 2010

Biomarkers of latent TB infection

Expert Review of Respiratory Medicine
Morten Ruhwald, Pernille Ravn

Abstract

For the last 100 years, the tuberculin skin test (TST) has been the only diagnostic tool available for latent TB infection (LTBI) and no biomarker per se is available to diagnose the presence of LTBI. With the introduction of M. tuberculosis-specific IFN-gamma release assays (IGRAs), a new area of in vitro immunodiagnostic tests for LTBI based on biomarker readout has become a reality. In this review, we discuss existing evidence on the clinical usefulness of IGRAs and the indefinite number of potential new biomarkers that can be used to improve diagnosis of latent TB infection. We also present early data suggesting that the monocyte-derived chemokine inducible protein-10 may be useful as a novel biomarker for the immunodiagnosis of latent TB infection.

Mentioned in this Paper

Tuberculosis, Meningeal
Chemokine
Latent Tuberculosis
Monocytes
Mycobacterium tuberculosis
Tuberculin Test
In Vitro [Publication Type]
Communicable Diseases
Immunodiagnosis

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