Biomarkers of metastatic melanoma

Biomarkers in Medicine
Monica NeaguIrina Margaritescu

Abstract

Melanoma, one of the most aggressive forms of human cancer, has undergone an alarming increase in incidence in recent years. Early detection is a prerequisite for proper diagnosis and therapy orientation. Soluble biomarkers are an important tool for early diagnosis. Markers that are associated with melanocyte functions imply the enzymes involved in melanin synthesis and the melanin-related metabolites. Proteins such as autocrine melanocyte cell growth factor and melanoma metastasis suppressor have gained attention in the biomarkers domain. The antimelanoma immune response elicited in patients can not only provide new biomarkers but important therapeutic approaches in specific treatments. All the molecules generated during the metastasis process, invasion of neighboring tissue, angiogenesis, invading lymphatic/blood vessels and establishing new tumors at a distant site, are targets for biomarker discovery.

References

Nov 1, 1992·The Journal of Dermatology·H HaraT Morishima
Nov 1, 1992·The Journal of Dermatology·T Horikoshi, Shosuke Ito
Nov 1, 1992·Seminars in Surgical Oncology·Charles M Balch
Jun 15, 1990·International Journal of Cancer. Journal International Du Cancer·D M EuhusDonald L Morton
Jun 15, 1989·Cancer·M J Wizenberg
Jan 15, 1971·International Journal of Cancer. Journal International Du Cancer·I HellströmG A Warner
Jun 9, 1965·Biochemical and Biophysical Research Communications·B W Moore
Mar 1, 1983·Cancer·S J FinckDonald L Morton
Jul 24, 1980·Nature·R GaynorH R Herschman
Dec 6, 1995·JAMA : the Journal of the American Medical Association·M WeissJ R O'Fallon
Nov 1, 1995·CA: a Cancer Journal for Clinicians·J A Hall
Jun 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H B GuoD Klingmüller
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y KawakamiS A Rosenberg
Nov 1, 1996·Annals of Surgical Oncology·G MiliotesD Reintgen
Jan 1, 1997·Acta Oncologica·A TofaniC L Maini
Jul 11, 1998·The Journal of Biological Chemistry·E R PriceDavid E Fisher
Jul 17, 1998·Melanoma Research·M R Ros-BullónJ H Martínez-Liarte
Dec 19, 1998·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·A K BosserhoffR Hein
May 3, 2000·Annals of Surgical Oncology·E C HsuehDonald L Morton
Jun 23, 2000·Annals of Surgical Oncology·N HabalDonald L Morton
Sep 14, 2000·Melanoma Research·R KärnellU Ringborg
Oct 21, 2000·Pigment Cell Research·David E Fisher
Nov 25, 2000·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·B SchittekC Garbe
Dec 9, 2000·Human Pathology·J DeedsL M Duncan
Feb 22, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M C KelleyDonald L Morton
Feb 24, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L M DuncanJ J McCarthy
Aug 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles M BalchJ F Thompson
Sep 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·X Z XuC Montell
Nov 16, 2001·Archives of Dermatology·J V Schaffer, J L Bolognia
Jul 12, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·U KeilholzA M M Eggermont
Aug 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L Andrew DiFronzoDonald L Morton
Nov 26, 2002·Immunological Reviews·Mary Jo TurkAlan Houghton
Mar 1, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giuseppe PalmieriGiuseppe Castello
Apr 25, 2003·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·R S PrichardN J O'Higgins
Jun 5, 2003·Nature Reviews. Cancer·Mary J C HendrixRichard E B Seftor
Jun 11, 2003·Annals of Medicine·Pia VihinenVeli-Matti Kähäri
Jul 10, 2003·Annals of the New York Academy of Sciences·Ana Luisa KadekaroZalfa A Abdel-Malek
Jun 16, 2004·CA: a Cancer Journal for Clinicians·Charles M BalchJohn F Thompson
Jul 6, 2004·Clinical Biochemistry·Riikka Harpio, Roland Einarsson
Jul 15, 2004·Pigment Cell Research·Keith W Vance, Colin R Goding
Sep 1, 2004·Journal of the American Academy of Dermatology·Timothy S WangJennifer L Schwartz
Sep 7, 2004·Expert Review of Molecular Diagnostics·Pietro QuaglinoMaria Grazia Bernengo
Nov 3, 2004·Journal of Dermatological Science·Takashi MurakamiSam T Hwang
Jan 20, 2005·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·Selma Ugurel
Feb 5, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Léonie H M SmitGijsbert C de Gast
Jun 30, 2005·Cancer Metastasis Reviews·Jon A ReedEstela E Medrano
Jul 22, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Johanna NikkolaSeppo Pyrhönen
Aug 11, 2005·Current Oncology Reports·Nicole Kounalakis, James S Goydos
Nov 9, 2005·Peptides·Paula C EvesJohn W Haycock
Nov 12, 2005·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Dirk J Ruiter, Meenhard Herlyn
Feb 8, 2006·Cancer·Christian KollmannsbergerCarsten Bokemeyer
Feb 17, 2006·Cancer Cell International·Fabio Grizzi, Maurizio Chiriva-Internati
Feb 17, 2006·The New England Journal of Medicine·Helen GogasJohn M Kirkwood
Mar 10, 2006·Pigment Cell Research·Kazumasa WakamatsuShosuke Ito
Apr 13, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Thomas F Gajewski
May 10, 2006·Clinical and Experimental Dermatology·G W M Millington
May 25, 2006·Frontiers in Bioscience : a Journal and Virtual Library·Jon A Reed, Estela E Medrano
Jun 6, 2006·Journal of Dermatological Science·Minoru Takata, Toshiaki Saida
Jul 18, 2006·Melanoma Research·Tanja Rothhammer, Anja-Katrin Bosserhoff
Jul 27, 2006·Neoplasia : an International Journal for Oncology Research·Weihua ZhangIsaiah J Fidler
Aug 4, 2006·Cancer Control : Journal of the Moffitt Cancer Center·M Aleem KhanAdil I Daud
Aug 17, 2006·Genes & Development·Lynda ChinDavid E Fisher
Aug 17, 2006·The Journal of Investigative Dermatology·Markus BöhmJosé Carlos García-Borrón
Jan 16, 2007·Archives of Dermatological Research·Jochen UtikalSelma Ugurel
Feb 6, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jean-Pierre GarnierThierry Le Bricon
Apr 18, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Zoya R YurkovetskyAnna E Lokshin
May 9, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Yubin Miao, Thomas P Quinn
Jun 15, 2007·Acta Oncologica·Pia VihinenSeppo Pyrhönen
Jul 31, 2007·Cancer Investigation·Mark B FariesDonald L Morton
Sep 1, 2007·Clinical & Experimental Metastasis·Pia VihinenSeppo Pyrhönen
Feb 20, 2008·Photochemistry and Photobiology·Zalfa A Abdel-MalekRenny Starner
Mar 1, 2008·International Journal of Clinical Oncology·Kazuyuki IshiharaPrognosis and Statistical Investigation Committee of the Japanese Skin Cancer Society
Apr 11, 2008·Journal of Cutaneous Pathology·Steven J OhsieScott W Binder
May 10, 2008·Annals of Surgical Oncology·Heather B NeumanDaniel G Coit
Jun 4, 2008·Journal of Leukocyte Biology·Lei FangSam T Hwang
Jun 6, 2008·Expert Review of Proteomics·Karim RezaulDavid K Han
Jun 20, 2008·The Journal of Investigative Dermatology·Kavita V ShahRandall T Moon
Aug 14, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Cédric MénardCaroline Robert
Aug 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gianni GerliniNicola Pimpinelli
Sep 24, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Craig L SlingluffPatrice K Rehm
Oct 11, 2008·American Journal of Clinical Oncology·Raquel AndrésAlejandro Tres
Nov 11, 2008·The Journal of Investigative Dermatology·Jeffrey S Weber

Citations

Jun 11, 2011·Biomarkers in Medicine·Konstantinos LinosJ Andrew Carlson
Nov 14, 2015·Journal of Immunoassay & Immunochemistry·Cristiana TanaseMonica Neagu
Oct 28, 2015·Mediators of Inflammation·Corina-Daniela EneIlinca Nicolae
Sep 27, 2016·Disease Markers·Simona MihaiCristiana Tanase
Nov 26, 2010·Cancer Treatment Reviews·Andrianos NezosMichael Koutsilieris
Mar 9, 2017·Melanoma Research·Monica FalleniGaetano P Bulfamante
Jan 11, 2018·Journal of Immunology Research·Mihaela SurcelMonica Neagu
Oct 23, 2010·Expert Review of Molecular Diagnostics·Monica NeaguCristiana Tanase
Sep 29, 2019·Cancer Biomarkers : Section a of Disease Markers·Alessia PaganelliRoberto Paganelli
Apr 5, 2019·Oncology Letters·Monica NeaguSabina Zurac
Jun 15, 2017·Journal of Immunoassay & Immunochemistry·Carmen DumitruMonica Neagu
Mar 19, 2020·Frontiers in Cell and Developmental Biology·Monica NeaguSabina Zurac

Related Concepts

Biological Markers
Malignant Neoplasms
Cell Growth
Melanoma
Neoplasms
Vascular Diseases
Proximal
Site
Metastatic Melanoma
Immune Response

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