Biomarkers of myocardial injury in rats after cantharidin poisoning: Application for postmortem diagnosis and estimation of postmortem interval.

Scientific Reports
Youyou ZhangLiang Ren

Abstract

Postmortem diagnosis of cantharidin-induced myocardial injury and postmortem interval estimation (PMI) are the challenges in forensic science. Cardiac biomarkers play an important role in the prediction and diagnosis of myocardial injury and can be used to determine the PMI. Based on the evidence, we aimed to explore the biomarkers which may be used for the postmortem diagnosis of cantharidin-induced myocardial injury and PMI estimation using the study of the proteins expression of TN-T, VEGF and HIF-1α by ELISA. Results of this study suggested that postmortem pathological changes were difficult to identify due to the autolysis of myocardium 72 h after death in cantharidin poisoning group. The plasma levels of TN-T and HIF-1α/TN-T are cardiac biomarkers with higher diagnostic accuracy for postmortem diagnosis of cantharidin-induced myocardial injury, VEGF/HIF-1α promises to be a biomarker for PMI estimation. Further studies are needed to verify these biomarkers, based on population, for being a useful tool in postmortem diagnosis of cantharidin-induced myocardial injury and PMI estimation.

References

Sep 1, 1992·Forensic Science International : Synergy·A PolettiniA Saragoni
Jan 1, 1990·Human & Experimental Toxicology·H K HundtL Wagner
Sep 1, 1996·Molecular and Cellular Biology·J A ForsytheG L Semenza
Jun 20, 2000·Toxicon : Official Journal of the International Society on Toxinology·D TagwireyiS Moyo
Apr 24, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sophie-Elise MichaudAlain Rivard
May 9, 2012·The EMBO Journal·Samantha N GreerMichael Ohh
Sep 24, 2013·Forensic Science International : Synergy·Lucas González-HerreraEnrique Villanueva
Dec 10, 2013·Forensic Science International : Synergy·S RemmerM Väli
Apr 1, 2013·Clinical Kidney Journal·Patrícia CotovioMário Campos
Mar 10, 2016·Forensic Science, Medicine, and Pathology·Lucas González-HerreraEnrique Villanueva
Mar 14, 2016·Journal of Forensic and Legal Medicine·Sachil KumarAnoop K Verma
Jul 30, 2017·Wilderness & Environmental Medicine·Buddhika T B Wijerathne
May 14, 2018·Regulatory Toxicology and Pharmacology : RTP·Youyou ZhangLiang Liu
Oct 1, 2018·Forensic Science International : Synergy·Caterina Barberi, Karen E van den Hondel
Mar 14, 2019·International Journal of Legal Medicine·Kyoung-Min ChoiStefan Pittner

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