Biomarkers of oral inflammation in perinatally HIV-infected and perinatally HIV-exposed, uninfected youth

Journal of Clinical Periodontology
Anna-Barbara MoscickiPediatric HIV/AIDS Cohort Study

Abstract

To examine oral biomarkers that have been associated with periodontal disease progression in HIV-infected adults in perinatally HIV-infected and HIV-exposed but uninfected youth. This was a cross-sectional, multicentre substudy of youth participating in the Oral Health Pediatric HIV/AIDS Cohort study. Gingival crevicular fluid repository samples from participants with and without periodontal disease (using Gingival Index [GI] and Bleeding on Probing [BOP] parameters on dental examination) were tested for concentration levels of inflammatory biomarkers. Associations were assessed using Wilcoxon test and Spearman correlation. For perinatal HIV youth (n = 129), the markers consistently elevated (p < .05) in sites with GI ≥2 and in sites with BOP were interleukin-1β, 6 and 13, macrophage inflammatory protein-1α and metalloproteinase-9. Serum tumour necrosis factor-α and soluble CD14 were positively correlated with a summary count of elevated cytokines. No associations were seen among HIV-uninfected subjects (n = 71). The association of oral biomarkers of inflammation with clinical indicators of periodontal inflammation and systemic immune activation suggests that perinatal HIV-infected youth may be at higher risk for developing sig...Continue Reading

Associated Clinical Trials

Aug 16, 2011·George Seage

References

May 1, 1991·Journal of Periodontal Research·R R Ranney
Aug 1, 1995·Bone·S C Manolagas
Mar 12, 1998·Journal of Clinical Periodontology·S S SocranskyR L Kent
Jul 17, 1998·Clinical and Diagnostic Laboratory Immunology·P NishanianJ L Fahey
Aug 15, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·Z LiuJ V Giorgi
Oct 2, 2001·Journal of Periodontology·B NoackE De Nardin
Oct 5, 2001·Journal of Periodontal Research·J KidoT Nagata
Dec 1, 1963·Acta Odontologica Scandinavica·H LOE, J SILNESS
Feb 6, 2004·Journal of Clinical Periodontology·T AlpagotA Lee
Nov 10, 2005·Journal of Periodontology·Robert J GencoYoji Murayama
Dec 29, 2006·Annals of the New York Academy of Sciences·Niki M Moutsopoulos, Phoebus N Madianos
Apr 25, 2009·Periodontology 2000·William V GiannobileDavid T Wong
Mar 17, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Russell B Van DykeUNKNOWN Pediatric HIV/AIDS Cohort Study
Mar 17, 2012·Journal of Periodontology·Paul I EkeRobert J Genco
Aug 23, 2012·Periodontology 2000·Mark I RyderJohn S Greenspan
Nov 10, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Katherine TassiopoulosUNKNOWN Pediatric HIV/AIDS Cohort Study
Feb 26, 2013·International Journal of Cancer. Journal International Du Cancer·Mark E ScottMarc T Goodman
Jun 19, 2013·Immunological Reviews·Huanbin XuRonald S Veazey
Jul 12, 2013·Science Translational Medicine·Ivan Vujkovic-CvijinJoseph M McCune
Nov 19, 2013·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Julie AlperenAnna-Barbara Moscicki
Dec 7, 2013·Journal of Clinical Periodontology·Janet S KinneyWilliam V Giannobile
Jan 28, 2014·Journal of Clinical Periodontology·Khady KâBelinda Nicolau
May 21, 2015·American Journal of Reproductive Immunology : AJRI·Loris Y HwangAnna-Barbara Moscicki
Jun 15, 2016·PloS One·Anna-Barbara MoscickiUNKNOWN Shiboski
Nov 2, 2016·Journal of Clinical Periodontology·Mark I RyderUNKNOWN Pediatric HIV/AIDS Cohort Study
Mar 23, 2017·Frontiers in Immunology·Samantha E Heron, Shokrollah Elahi
May 23, 2017·International Journal of Dentistry·Maélson Klever da SilvaDaniel Fernando Pereira Vasconcelos

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