PMID: 18403884Apr 12, 2008Paper

Biomarkers of periodontitis in oral fluids

Journal of Oral Science
Balwant RaiSuresh C Anand

Abstract

Matrix metalloproteinases (MMPs), the key enzymes responsible for matrix degradation, are derived from polymorphonuclear leukocytes during the early stages of periodontitis. The present study determined the levels of GCF matrix metalloproteinase-2 (MMP-2) and metalloproteinase-9 (MMP-9) and salivary MMP-8 in patients with gingivitis and periodontitis and in healthy controls. Levels of crevicular MMP-2, MMP-9 and salivary MMP-8 were determined by ELISA in subjects with healthy gingiva (n = 15), gingivitis (n = 18) and periodontitis (n = 20). Significantly higher salivary MMP-8 and crevicular MMP-9 were observed in cases of periodontitis compared to gingivitis and healthy adults. On the other hand, crevicular MMP-2 levels in periodontitis subjects were lower than those in gingivitis and healthy subjects. The three MMP levels were highly correlated to probing depth, and bleeding on probing. Salivary MMP-8, crevicular MMP- 2 and 9 may serve as biomarkers of periodontal disease and aid in early detection of periodontitis or gingivitis.

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Citations

Jun 1, 2012·Journal of Molecular Histology·Junsheng FengShuo Chen
Jun 11, 2014·PloS One·J Max GoodsonFrancine Welty
May 11, 2010·Journal of Periodontology·Anna Maria HeikkinenJukka H Meurman
Jun 11, 2011·The Angle Orthodontist·Wellington J RodyGetulio Nogueira Filho
Apr 30, 2010·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·Balwant RaiKuldeep Laller
Oct 7, 2011·Journal of Indian Society of Periodontology·Sujeet V KhisteV Rajani
Jun 20, 2014·ISRN Inflammation·John J Taylor
Feb 4, 2014·International Journal of Proteomics·Harpreet Singh GroverNeha Saksena
Jul 23, 2013·Acta Odontologica Scandinavica·Daniela MiricescuMaria Greabu
Dec 19, 2015·Expert Review of Molecular Diagnostics·Jason TasoulasStamatios Theocharis
Mar 25, 2011·Clinical Implant Dentistry and Related Research·Ceyda Özçakır-TomrukRegina Mericske-Stern
Mar 11, 2011·Cytokine & Growth Factor Reviews·Eline DejonckheereClaude Libert
Oct 27, 2015·Acta Biomaterialia·Govinda BhattaraiJeong-Chae Lee
Sep 10, 2010·Journal of Clinical Periodontology·Martha Eugenia FajardoEmanuel Jaime Espinosa-Chávez
Feb 1, 2011·Journal of Investigative and Clinical Dentistry·Daniel GrenierGuy Gagnon
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Feb 22, 2011·Oral Diseases·P E Sánchez-HernándezC Guerrero-Velázquez
Feb 26, 2011·Journal of Clinical Periodontology·Nurcan Buduneli, Denis F Kinane
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Jun 8, 2012·Journal of Clinical Periodontology·Ariadne LetraAlexandre R Vieira
Jul 16, 2013·Oral Diseases·G SapnaK Bagri-Manjrekar
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Jul 15, 2015·Statistics in Medicine·Su Chen, Thomas M Braun
Jul 22, 2011·Archives of Oral Biology·Sausan Al KawasDavid B Ferguson

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