Biomarkers of Physiological Responses to Periods of Intensified, Non-Resistance-Based Exercise Training in Well-Trained Male Athletes: A Systematic Review and Meta-Analysis

Sports Medicine
Grace GreenhamKevin Norton

Abstract

Intensified training is important for inducing adaptations to improve athletic performance, but detrimental performance effects can occur if prescribed inappropriately. Monitoring biomarker responses to training may inform changes in training load to optimize performance. This systematic review and meta-analysis aimed to identify biomarkers associated with altered exercise performance following intensified training. Embase, MEDLINE, CINAHL, Scopus and SPORTDiscus were searched up until September 2017. Included articles were peer reviewed and reported on biomarkers collected at rest in well-trained male athletes before and after periods of intensified training. The full text of 161 articles was reviewed, with 59 included (708 participants) and 42 (550 participants) meta-analysed. In total, 118 biomarkers were evaluated, with most being cellular communication and immunity markers (n = 54). Studies most frequently measured cortisol (n = 34), creatine kinase (n = 25) and testosterone (n = 20). Many studies reported decreased immune cell counts following intensified training, irrespective of performance. Moreover, reduced performance was associated with a decrease in neutrophils (d = - 0.57; 95% confidence interval (CI) - 1.07 to - ...Continue Reading

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Citations

May 1, 2019·Sports·Naroa EtxebarriaDavid Bruce Pyne
Feb 14, 2019·The Journal of Sports Medicine and Physical Fitness·Joel M GarrettKevin Norton
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Dec 29, 2021·Applied Neuropsychology. Adult·Leonardo Sousa FortesMaria Elisa Caputo Ferreira
Jun 4, 2021·The Journal of Sports Medicine and Physical Fitness·Michele AbateVincenzo Salini

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