Biomarkers of preconception stress and the incidence of pregnancy loss

Human Reproduction
Courtney D LynchG M Buck Louis

Abstract

Are biomarkers of preconception stress associated with pregnancy loss? Preconception stress, as measured by basal salivary cortisol and alpha-amylase concentrations, is not associated with pregnancy loss. Many studies, most of which have been retrospective, have identified an association between stressful life events and perceived stress and miscarriage. A prospective pregnancy study with preconception enrollment was conducted between 2005 and 2009. Among the 344 women who became pregnant during the Longitudinal Investigation of Fertility and the Environment (LIFE) study, 337 (98%) had salivary biomarker data for analysis. Couples planning pregnancy were followed for up to 12 months as they tried to become pregnant and through pregnancy if it occurred. Participating women collected a basal saliva sample on the morning following enrollment and a second on the morning following their next menses to measure cortisol and alpha-amylase, biomarkers of stress. Women used home pregnancy tests on the day of expected menses. A pregnancy loss was defined as a negative pregnancy test following a positive pregnancy test, the onset of menses, or for pregnancies that survived to clinical recognition, recognition of the loss by a healthcare pr...Continue Reading

References

Oct 1, 1977·Journal of Medical Genetics·E D Alberman, M R Creasy
Oct 11, 1990·The New England Journal of Medicine·M A KlebanoffG G Rhoads
Jul 28, 1988·The New England Journal of Medicine·A J WilcoxB C Nisula
Jul 1, 1971·The Journal of Clinical Endocrinology and Metabolism·E D WeitzmanL Hellman
Dec 1, 1995·American Journal of Epidemiology·L FensterS H Swan
Mar 15, 1996·American Journal of Epidemiology·R NeugebauerM Susser
Dec 1, 1995·The British Journal of Psychiatry : the Journal of Mental Science·T O'Hare, F Creed
Jun 1, 1997·Journal of Occupational and Environmental Medicine·M B SchenkerS Samuels
Oct 2, 1998·Human Reproduction·M P MiladR Chatterton
Jan 15, 1999·Epidemiology·S GreenlandJ M Robins
Jun 9, 1999·Scandinavian Journal of Work, Environment & Health·M C HatchS Salerno
Oct 12, 2000·Baillière's Best Practice & Research. Clinical Obstetrics & Gynaecology·L Regan, R Rai
Oct 12, 2000·Baillière's Best Practice & Research. Clinical Obstetrics & Gynaecology·M Goddijn, N J Leschot
May 5, 2001·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·H Bashour, A Abdul Salam
Jan 1, 2003·Clinical Chemistry·Hershel RaffDavid P Skoner
Sep 16, 2004·American Journal of Human Biology : the Official Journal of the Human Biology Council·Pablo A NepomnaschyBarry G England
Apr 14, 2005·Endocrine Reviews·John R Lindsay, Lynnette K Nieman
Feb 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Pablo A NepomnaschyBarry G England
Mar 3, 2007·Annals of the New York Academy of Sciences·Douglas A GrangerLaura R Stroud
Apr 10, 2007·Psychoneuroendocrinology·Urs M NaterClemens Kirschbaum
Dec 20, 2007·Epidemiology·David A SavitzKatherine E Hartmann
Jul 12, 2008·Reproductive Biomedicine Online·Petra C ArckBurghard F Klapp
Aug 7, 2010·Fertility and Sterility·Germaine M Buck LouisCecilia Pyper
Oct 3, 2014·Clinical Chemistry and Laboratory Medicine : CCLM·Sarah JohnsonJoanna Pike
Nov 14, 2015·Psychoneuroendocrinology·Tobias StalderAngela Clow
Mar 27, 2016·Fertility and Sterility·Germaine M Buck LouisRajeshwari Sundaram

❮ Previous
Next ❯

Citations

May 1, 2020·International Journal of Environmental Research and Public Health·Diana C Santa-CruzJuan Antonio García-Velasco
Jan 5, 2019·Irish Journal of Medical Science·Indra San Lazaro CampilloKeelin O'Donoghue
Nov 20, 2020·Statistics in Medicine·Paramita Saha-Chaudhuri, Lamin Juwara
Feb 3, 2021·JAAPA : Official Journal of the American Academy of Physician Assistants·Toni Jackson, Elyse Watkins
Nov 16, 2021·Clinics in Dermatology·Ellen M S XerfanMonica L Andersen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.