Biomarkers of selenium status in dogs

BMC Veterinary Research
Mariëlle van ZelstGeert P J Janssens

Abstract

Inadequate dietary selenium (Se) intake in humans and animals can lead to long term health problems, such as cancer. In view of the owner's desire for healthy longevity of companion animals, the impact of dietary Se provision on long term health effects warrants investigation. Little is currently known regards biomarkers, and rate of change of such biomarkers in relation to dietary selenium intake in dogs. In this study, selected biomarkers were assessed for their suitability to detect changes in dietary Se in adult dogs within eight weeks. Twenty-four dogs were fed a semi-purified diet with an adequate amount of Se (46.1 μg/MJ) over an 8 week period. They were then divided into two groups. The first group remained on the adequate Se diet, the second were offered a semi-purified diet with a low Se concentration (6.5 μg/MJ; 31% of the FEDIAF minimum) for 8 weeks. Weekly urine and blood was collected and hair growth measurements were performed. The urinary Se to creatinine ratio and serum Se concentration were significantly lower in dogs consuming the low Se diet from week 1 onwards, by 84% (adequate 25.3, low 4.1) and 7% (adequate 257 μg/L, low 238 μg/L) respectively. Serum and whole blood glutathione peroxidase were also signif...Continue Reading

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May 23, 2015·The British Journal of Nutrition·Mariëlle van ZelstGeert P J Janssens

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Citations

Feb 11, 2021·Animals : an Open Access Journal From MDPI·Viola ZentrichováSimona Kovaříková
Jun 29, 2018·Journal of Agricultural and Food Chemistry·Ana Margarida PereiraAna R J Cabrita

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Methods Mentioned

BETA
urine collection
enzyme-linked immunosorbent assay
RNA Assay

Software Mentioned

nlme package
Excel
Fold
Primer3
R Foundation for Statistical Computing
MxPro
R
geNorm
ImageJ

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