Biomarkers of susceptibility following benzene exposure: influence of genetic polymorphisms on benzene metabolism and health effects

Biomarkers in Medicine
Damiano CarbonariGiovanna Tranfo

Abstract

Benzene is a ubiquitous occupational and environmental pollutant. Improved industrial hygiene allowed airborne concentrations close to the environmental context (1-1000 µg/m(3)). Conversely, new limits for benzene levels in urban air were set (5 µg/m(3)). The biomonitoring of exposure to such low benzene concentrations are performed measuring specific and sensitive biomarkers such as S-phenylmercapturic acid, trans, trans-muconic acid and urinary benzene: many studies referred high variability in the levels of these biomarkers, suggesting the involvement of polymorphic metabolic genes in the individual susceptibility to benzene toxicity. We reviewed the influence of metabolic polymorphisms on the biomarkers levels of benzene exposure and effect, in order to understand the real impact of benzene exposure on subjects with increased susceptibility.

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Citations

Nov 4, 2016·International Journal of Environmental Research and Public Health·Rongli SunYuepu Pu
Oct 21, 2017·Biomarkers in Medicine·Pieranna ChiarellaGiovanna Tranfo
Nov 12, 2019·Environmental and Molecular Mutagenesis·Mirjam LuijtenJan van Benthem
Dec 8, 2017·Journal of Cellular Physiology·Shu-Jie HuangAndy T Y Lau
Jun 3, 2021·Cancers·Giovanna SpatariSebastiano Gangemi
Jul 24, 2021·Health Science Reports·Verónica Ramírez-LoperaTania Liseth Pérez-Cala
Sep 23, 2021·Molecular Genetics & Genomic Medicine·Imen HemissiSlah Ouerhani

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Methods Mentioned

BETA
chromosomal aberrations

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