Biomarkers of Systemic Inflammation and Growth in Early Infancy are Associated with Stunting in Young Tanzanian Children

Nutrients
Sana SyedChristopher P Duggan

Abstract

Stunting can afflict up to one-third of children in resource-constrained countries. We hypothesized that low-grade systemic inflammation (defined as elevations in serum C-reactive protein or alpha-1-acid glycoprotein) in infancy suppresses the growth hormone⁻insulin-like growth factor (IGF) axis and is associated with subsequent stunting. Blood samples of 590 children from periurban Dar es Salaam, Tanzania, were obtained at 6 weeks and 6 months of age as part of a randomized controlled trial. Primary outcomes were stunting, underweight, and wasting (defined as length-for-age, weight-for-age and weight-for-length z-scores < -2) between randomization and endline (18 months after randomization). Cox proportional hazards models were constructed to estimate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) of time to first stunting, underweight, and wasting as outcomes, with measures of systemic inflammation, insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) as exposures, adjusting for numerous demographic and clinical variables. The incidences of subsequent stunting, underweight, and wasting were 26%, 20%, and 18%, respectively. In multivariate analyses, systemic infl...Continue Reading

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Citations

Jan 23, 2019·The Indian Journal of Medical Research·V Sudhakar ReddyG Bhanuprakash Reddy
May 30, 2019·Proceedings of the National Academy of Sciences of the United States of America·Carrie A CowardinJeffrey I Gordon
Dec 3, 2020·BMC Medical Genetics·Luojia XuJie Chen
Jul 26, 2019·Cellular and Molecular Gastroenterology and Hepatology·Arthur J KastlLindsey G Albenberg

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Methods Mentioned

BETA
ELISA

Clinical Trials Mentioned

NCT00421668

Software Mentioned

SAS
Access

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