Biomarkers of the prothrombotic state in abdominal obesity

Nutrición hospitalaria
Marcela MontillaFélix A Ruiz

Abstract

Central obesity is specifically associated with cardiovascular disease. Nevertheless, the molecular events that promote these conditions remain incompletely defined and risk stratifying patients for cardiovascular disease continues a challenge. The aim of this study was to assess some cost-efficient haemostatic markers, and its association with central obesity and traditional cardiovascular risk factors, in a cohort of middle aged subjects, without clinical cardiovascular disease, as basis for an improved prevention and intervention. We studied 307 men, aged 45±7 years, which underwent medical history, physical examination, anthropometric measurements, plasmatic biochemical parameters, plasma concentrations of fibrinogen, prothrombin activity, activated partial thromboplastin time, platelet count and mean platelet volume. Prothrombin activity values were significantly higher in patients with central obesity (103 ± 16 % vs 111 ± 17 %, p<0.001). Across tertiles of fibrinogen (low and high), there was an increase in cholesterol, adjusted for age and body mass index (4.9±0.9 mmol/L vs 5.4±1.1 mmol/L, p< 0.01). High tertile of prothrombin activity showed higher levels of cholesterol (4.8±1.0 mmol/L vs 5.4±0.9 mmol/L , p< 0.05), trig...Continue Reading

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