Biomarkers of vascular dysfunction and cognitive decline in patients with Alzheimer's disease: no evidence for association in elderly subjects

Aging Clinical and Experimental Research
Alice BreiningJacques Boddaert

Abstract

Several studies have suggested that vascular dysfunction plays an important role in Alzheimer's disease. We hypothesized that significant differences might be observed in the levels of blood endothelial biomarkers across elderly population of subjects with dementia. We analyzed, in a prospective monocentric study, three different endothelial biomarkers, endothelial microparticles (EMPs), endothelial progenitor cells (EPCs) and circulating endothelial cells (CECs) in 132 older patients who underwent a full evaluation of a memory complaint. There was no difference in specific EMP, EPC or CEC levels between demented or non-demented patients, nor considering cognitive decline. Blood endothelial biomarkers may be too sensitive and it is likely that the multimorbidity observed in our patients may lead to opposite and confounding effects on endothelial biomarkers levels. Unlike younger AD patients, our results suggest that endothelial biomarkers are not valuable for the diagnosis of dementia in elderly patients.

References

Feb 14, 2003·The New England Journal of Medicine·Jonathan M HillToren Finkel
Aug 30, 2003·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Kenneth RockwoodHoward Feldman
Sep 3, 2004·Journal of the American Geriatrics Society·Robert G RiekseDebby Tsuang
Sep 18, 2004·Stroke; a Journal of Cerebral Circulation·Alex E RoherThomas G Beach
Sep 18, 2004·Stroke; a Journal of Cerebral Circulation·Philip B Gorelick
Aug 19, 2005·Journal of the American Society of Nephrology : JASN·Carolina HolménSuchitra Sumitran-Holgersson
Sep 9, 2005·The New England Journal of Medicine·Nikos WernerGeorg Nickenig
Jul 14, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Uta ErdbrueggerAlexander Woywodt
Jun 27, 2008·Annales de cardiologie et d'angéiologie·C-M BoulangerA Tedgui
May 28, 2009·Neurology·S-T LeeJ-K Roh
Mar 24, 2010·Journal of Alzheimer's Disease : JAD·Soon-Tae LeeJae-Kyu Roh
Oct 16, 2010·Neuropathology and Applied Neurobiology·W R Brown, C R Thore
Sep 14, 2011·Archives of Neurology·Christian SchmidtInga Zerr
Oct 19, 2012·Dementia and Geriatric Cognitive Disorders·Shouru XueGuozhen Hui
Jul 25, 2014·Nature·Luigi FontanaSimon Melov
Aug 16, 2014·World Journal of Stem Cells·Poay Sian Sabrina Lee, Kian Keong Poh
Nov 27, 2014·Alzheimer's Research & Therapy·Kaarin J Anstey, Roger A Dixon

❮ Previous
Next ❯

Citations

Nov 6, 2017·Journal of Alzheimer's Disease : JAD·Daniel A NationAimée Gaubert
Apr 11, 2018·Hypertension·Rosa Maria BrunoUNKNOWN Train the Brain Consortium

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.