Biomarkers of vascular injury in relation to myocardial infarction risk: A population-based study

Scientific Reports
Laura Pletsch-BorbaTilman Kühn

Abstract

Little is known about circulating biomarkers of vascular injury in relation to cardiovascular disease risk. Thus, we evaluated associations between six novel markers (E-Selectin, P-Selectin, thrombomodulin, thrombopoietin, intercellular adhesion molecule 3 and GPIIb/IIIa) and established cardiovascular risk factors as well as the risk of myocardial infarction (MI) in a population-based study. Biomarkers were measured in pre-diagnostic plasma samples of a case-cohort subset of EPIC-Heidelberg (incident MI cases: n = 369, random sub-cohort: n = 2,418). Generalized Linear models were used to analyse cross-sectional associations between biomarkers and cardiovascular risk factors. Multivariable Cox Regression analyses were carried out to obtain Hazard Ratios (HRs) of MI across quartiles of biomarkers levels. Cross-sectional analyses showed that sex, smoking, alcohol consumption, diabetes and exogenous hormone use were associated with biomarker levels. However, while fibrinogen was associated with MI risk (HR per standard deviation: 2.97 [95% confidence interval: 1.61, 5.46]), none of the six novel biomarkers was associated with MI risk after multivariable adjustment. In a population-based cohort, biomarkers of vascular injury were a...Continue Reading

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Citations

May 7, 2020·Neurology·Laura Pletsch-BorbaTilman Kühn
Jul 14, 2020·Current Pathobiology Reports·Roberto I MotaEdward M Bahnson
Dec 1, 2019·Journal of Clinical Medicine·Laura Pletsch-BorbaTilman Kühn

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Methods Mentioned

BETA
hormone replacement therapy
enzyme-linked immunosorbent assays

Software Mentioned

SAS
R

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