Biomarkers to diagnose ventricular dysfunction in childhood cancer survivors: a systematic review

Heart
Jan M LeerinkWouter E M Kok

Abstract

To systematically review the literature and assess the diagnostic value of biomarkers in detection of late-onset left ventricular (LV) dysfunction in childhood cancer survivors (CCS) treated with anthracyclines. We systematically searched the literature for studies that evaluated the use of biomarkers for detection of LV dysfunction in CCS treated with anthracyclines more than 1 year since childhood cancer diagnosis. LV dysfunction definitions were accepted as an ejection fraction <50% or <55% and/or a fractional shortening <28%, <29% or <30%. Contingency tables were created to assess diagnostic accuracies of biomarkers for diagnosing LV dysfunction. Of 1362 original studies screened, eight heterogeneous studies evaluating four different biomarkers in mostly asymptomatic CCS were included. In four studies, an abnormal N-terminal pro-B-type natriuretic peptide (NT-proBNP, cut-off range 63-125 ng/L) had low sensitivity (maximally 22%) and a specificity of up to 97% for detection of LV dysfunction. For troponin levels, in five studies one patient had an abnormal troponin value as well as LV dysfunction, while in total 127 patients had LV dysfunction without troponin elevations above cut-off values (lowest 0.01 ng/mL). Two studies ...Continue Reading

References

Jun 11, 1994·BMJ : British Medical Journal·D G Altman, J M Bland
Jul 9, 1994·BMJ : British Medical Journal·D G Altman, J M Bland
May 2, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·V B Pai, M C Nahata
Jan 31, 2004·Pediatric Blood & Cancer·Erol KismetMünevver Büyükpamukçu
Jul 20, 2004·BMJ : British Medical Journal·Jonathan J Deeks, Douglas G Altman
Dec 16, 2006·Pediatric Blood & Cancer·Sanjeev AggarwalThomas L'Ecuyer
Jun 28, 2007·JAMA : the Journal of the American Medical Association·Maud M GeenenFlora E van Leeuwen
Oct 14, 2008·Pediatric Hematology and Oncology·Annelies M C Mavinkurve-GroothuisJacqueline Groot-Loonen
Jan 8, 2009·Pediatric Blood & Cancer·Annelies M C Mavinkurve-GroothuisLivia Kapusta
Apr 2, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Angela B MariottoEric J Feuer
Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
Jul 28, 2010·Archives of Internal Medicine·Helena J van der PalLeontien C Kremer
Nov 17, 2010·JAMA : the Journal of the American Medical Association·Christopher R deFilippiStephen L Seliger
Jun 24, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Cornelia A J BrouwerJourik A Gietema
Jun 28, 2011·Pediatric Hematology and Oncology·Elif GulerAyse Balat
Aug 26, 2011·The American Journal of Cardiology·Michael G FradleyThomas J Wang
Mar 1, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Steven E LipshultzStephen E Sallan
Apr 5, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Helena J van der PalLeontien C Kremer
Oct 13, 2012·Journal of Experimental & Clinical Cancer Research : CR·Beata MladosievicovaIveta Simkova
Jun 13, 2013·JAMA : the Journal of the American Medical Association·Melissa M HudsonLeslie L Robison
Dec 10, 2013·The Lancet Oncology·Gemma GattaUNKNOWN EUROCARE Working Group
Oct 8, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric J ChowYutaka Yasui
Dec 17, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Milanthy S PourierAnnelies M C Mavinkurve-Groothuis
Mar 11, 2015·The Lancet Oncology·Saro H ArmenianUNKNOWN International Late Effects of Childhood Cancer Guideline Harmonization Group
Oct 30, 2015·BMJ : British Medical Journal·Patrick M BossuytUNKNOWN STARD Group
May 1, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jerzy R KowalczykGilles Vassal
Aug 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E SieswerdaUNKNOWN Late Effects of Childhood Cancer task force of the Dutch Childhood Oncology Group (DCOG LATER)

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Citations

Dec 13, 2019·Circulation. Cardiovascular Imaging·Martijn G SliekerLuc Mertens
Mar 12, 2019·Current Treatment Options in Cardiovascular Medicine·Jyothsna Akam-VenkataSanjeev Aggarwal
Jul 9, 2021·Basic & Clinical Pharmacology & Toxicology·Muhammad Erfan UddinAlex Sparreboom
Nov 4, 2021·Current Heart Failure Reports·Dongqing ChenAaron L Sverdlov

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