Biomaterial Scaffolds Recruit an Aggressive Population of Metastatic Tumor Cells In Vivo

Cancer Research
Grace G BushnellLonnie D Shea

Abstract

For most cancers, metastasis is the point at which clinical treatment shifts from curative intent to extending survival. Biomaterial implants acting as a synthetic premetastatic niche recruit metastatic cancer cells and provide a survival advantage, and their use as a diagnostic platform requires assessing their relevance to disease progression. Here, we showed that scaffold-captured tumor cells (SCAF) were 30 times more metastatic to the lung than primary tumor (PT) cells, similar to cells derived from lung micrometastases (LUNG). SCAF cells were more aggressive in vitro, demonstrated higher levels of migration, invasion, and mammosphere formation, and had a greater proportion of cancer stem cells than PT. SCAF cells were highly enriched for gene expression signatures associated with metastasis and had associated genomic structural changes, including globally enhanced entropy. Collectively, our findings demonstrate that SCAF cells are distinct from PT and more closely resemble LUNG, indicating that tumor cells retrieved from scaffolds are reflective of cells at metastatic sites. SIGNIFICANCE: These findings suggest that metastatic tumor cells captured by a biomaterial scaffold may serve as a diagnostic for molecular staging of...Continue Reading

References

Aug 14, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T YonedaR Nishimura
Jul 5, 2003·Cancer Cell·Yibin KangJoan Massagué
Dec 19, 2003·Nucleic Acids Research·M A HarrisUNKNOWN Gene Ontology Consortium
Nov 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ina H BenoyLuc Y Dirix
Jul 29, 2005·Nature·Andy J MinnJoan Massagué
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aravind SubramanianJill P Mesirov
Nov 18, 2006·Cell·Gaorav P Gupta, Joan Massagué
Dec 23, 2006·Cancer Metastasis Reviews·Rosandra N KaplanDavid Lyden
Aug 25, 2007·Cancer Metastasis Reviews·Simi Ali, Gwendal Lazennec
Nov 13, 2007·Advances in Experimental Medicine and Biology·Ana Maria Gonzalez-AnguloGabriel N Hortobagyi
May 8, 2009·Nature·Paula D BosJoan Massagué
May 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Brandon L PierceCornelia M Ulrich
Jun 25, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B K LinderholmR Lewensohn
Feb 23, 2010·Nature Cell Biology·Li MaRobert A Weinberg
Sep 2, 2010·PloS One·Regina Berretta, Pablo Moscato
Nov 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jungwoo LeeBiju Parekkadan
Mar 15, 2013·Molecular Imaging and Radionuclide Therapy·Yusuf Emre Erdi
Apr 9, 2013·Molecular and Cellular Endocrinology·Andrew R Chin, Shizhen Emily Wang
Sep 18, 2013·Breast Cancer Research : BCR·Jagdeep K SinghRobert B Clarke
Mar 21, 2015·PLoS Computational Biology·Christopher R S BanerjiAndrew E Teschendorff
Jun 17, 2015·Proceedings of the National Academy of Sciences of the United States of America·Haiming ChenIndika Rajapakse
Jul 8, 2015·Journal of the National Cancer Institute·Alexandre de la FuenteMiguel Abal
Sep 9, 2015·Nature Communications·Samira M AzarinLonnie D Shea
Nov 6, 2015·Nature Reviews. Cancer·Adam A FriedmanKeith T Flaherty
Dec 5, 2015·Scientific Reports·Brian A AguadoLonnie D Shea
Jan 16, 2016·Cell Systems·Arthur LiberzonPablo Tamayo
Mar 13, 2016·Cancer Discovery·Catherine Alix-Panabières, Klaus Pantel
Mar 5, 2017·Molecular Cancer Research : MCR·Laura SeamanIndika Rajapakse
Mar 18, 2017·Nature Reviews. Cancer·Héctor PeinadoDavid Lyden
Jul 25, 2017·Methods : a Companion to Methods in Enzymology·Thomas Ried, Indika Rajapakse
Oct 11, 2017·Nature Biomedical Engineering·Brian A AguadoLonnie D Shea

❮ Previous
Next ❯

Citations

May 16, 2020·Cancer Research·Aaron H MorrisLonnie D Shea
Jan 1, 2021·Cancers·Allison A FitzgeraldLouis M Weiner
Jul 7, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Vahid MansouriNima Rezaei

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.