Biomaterial-tight junction interaction and potential impacts

Journal of Materials Chemistry. B, Materials for Biology and Medicine
Xiangfei HanZhiqiang Cao

Abstract

The active pharmaceutical ingredients (APIs) have to cross the natural barriers and get into the blood to impart the pharmacological effects. The tight junctions (TJs) between the epithelial cells serve as the major selectively permeable barriers and control the paracellular transport of the majority of hydrophilic drugs, in particular, peptides and proteins. TJs perfectly balance the targeted transport and the exclusion of other unexpected pathogens under the normal conditions. Many biomaterials have shown the capability to open the TJs and improve the oral bioavailability and targeting efficacy of the APIs. Nevertheless, there is limited understanding of the biomaterial-TJ interactions. The opening of the TJs further poses the risk of autoimmune diseases and infections. This review article summarizes the most updated literature and presents insights into the TJ structure, the biomaterial-TJ interaction mechanism, the benefits and drawbacks of TJ disruption, and methods for evaluating such interactions.

References

Jul 1, 1987·The American Journal of Physiology·J L Madara
Jun 1, 1994·Journal of Cellular Physiology·R O StuartS K Nigam
Jun 1, 1996·Journal of Pharmaceutical Sciences·M TomitaS Awazu
Feb 5, 2000·American Journal of Respiratory Cell and Molecular Biology·G WangP B McCray
Jun 2, 2000·Gastroenterology·T KinugasaH C Reinecker
Nov 4, 2000·American Journal of Respiratory Cell and Molecular Biology·C B CoyneL G Johnson
Jan 5, 2002·Expert Opinion on Investigational Drugs·S I Rapoport
May 22, 2002·Brain Research·M KapuralD Janigro
Jun 19, 2002·Pharmaceutical Research·Andreas E ClausenAndreas Bernkop-Schnürch
Nov 15, 2002·Journal of Cell Science·Salah AmashehMichael Fromm
Apr 4, 2003·International Archives of Allergy and Immunology·Yoshinori Mine, Jie Wie Zhang
May 1, 1963·The Journal of Cell Biology·M G FARQUHAR, G E PALADE
Apr 7, 2004·Journal of Pharmaceutical Sciences·Noha N SalamaNatalie D Eddington
Jun 1, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Matthias BruewerAsma Nusrat
Dec 3, 2005·Journal of Inorganic Biochemistry·Yue ZhangDebbie C Crans
Jan 13, 2006·Laboratory Investigation; a Journal of Technical Methods and Pathology·Stephanie A BlairJerrold R Turner
Feb 8, 2006·Annual Review of Physiology·Christina M Van Itallie, James M Anderson
Mar 7, 2006·Advanced Drug Delivery Reviews·Noha N SalamaAlessio Fasano
Mar 28, 2007·Digestive Diseases and Sciences·Waddah A AlrefaiPradeep K Dudeja
Apr 10, 2007·The Journal of Surgical Research·Lisa S PoritzWalter A Koltun
May 22, 2007·Transplant Infectious Disease : an Official Journal of the Transplantation Society·H ArslanM Haberal
Sep 4, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Dong Yun LeeYoungro Byun
Oct 26, 2007·American Journal of Physiology. Renal Physiology·Ruchira Singh, Philine Wangemann
Jan 17, 2008·Journal of Cell Science·Christina M Van ItallieJames M Anderson
Sep 19, 2008·Current Gastroenterology Reports·Christopher W Teshima, Jon B Meddings
Oct 4, 2008·International Journal of Pharmaceutics·Shobha GopalakrishnanSefik S Alkan

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Citations

Nov 17, 2020·Frontiers in Molecular Biosciences·Sebastián Scioli MontotoMaría Esperanza Ruiz

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Methods Mentioned

BETA
fluorescence recovery
urine collecting

Software Mentioned

TEER

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