Biomaterializing the promise of cardiac tissue engineering.

Biotechnology Advances
Jordan E PomeroyNenad Bursac

Abstract

During an average individual's lifespan, the human heart pumps nearly 200 million liters of blood delivered by approximately 3 billion heartbeats. Therefore, it is not surprising that native myocardium under this incredible demand is extraordinarily complex, both structurally and functionally. As a result, successful engineering of adult-mimetic functional cardiac tissues is likely to require utilization of highly specialized biomaterials representative of the native extracellular microenvironment. There is currently no single biomaterial that fully recapitulates the architecture or the biochemical and biomechanical properties of adult myocardium. However, significant effort has gone toward designing highly functional materials and tissue constructs that may one day provide a ready source of cardiac tissue grafts to address the overwhelming burden of cardiomyopathic disease. In the near term, biomaterial-based scaffolds are helping to generate in vitro systems for querying the mechanisms underlying human heart homeostasis and disease and discovering new, patient-specific therapeutics. When combined with advances in minimally-invasive cardiac delivery, ongoing efforts will likely lead to scalable cell and biomaterial technologie...Continue Reading

Citations

Apr 20, 2020·Heart Failure Reviews·Haotong LiYu Nie
Jul 30, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Alejandra Patino-GuerreroMehdi Nikkhah
Oct 25, 2020·Stem Cell Reviews and Reports·Pallavi PushpMukesh Kumar Gupta
Nov 27, 2020·Frontiers in Cardiovascular Medicine·Ravi K Birla
Feb 6, 2021·International Journal of Molecular Sciences·Karine TadevosyanAngel Raya
Mar 16, 2021·Frontiers in Cardiovascular Medicine·Lu WangJianyi Zhang
May 23, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zhi ZhengHua Wei
Jun 22, 2021·Frontiers in Bioengineering and Biotechnology·Mira ChingaleKe Huang
Aug 24, 2021·Journal of Biomedical Materials Research. Part a·Chiara Emma CampiglioLorenza Draghi
Sep 14, 2021·ACS Biomaterials Science & Engineering·Hossein RavanbakhshYu Shrike Zhang
Jan 14, 2022·Chemical Reviews·Yue ZhaoYanli Zhao

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