Biomaterials-Based Opportunities to Engineer the Pulmonary Host Immune Response in COVID-19.

ACS Biomaterials Science & Engineering
Bader M JaraiCatherine A Fromen

Abstract

The COVID-19 pandemic caused by the global spread of the SARS-CoV-2 virus has led to a staggering number of deaths worldwide and significantly increased burden on healthcare as nations scramble to find mitigation strategies. While significant progress has been made in COVID-19 diagnostics and therapeutics, effective prevention and treatment options remain scarce. Because of the potential for the SARS-CoV-2 infections to cause systemic inflammation and multiple organ failure, it is imperative for the scientific community to evaluate therapeutic options aimed at modulating the causative host immune responses to prevent subsequent systemic complications. Harnessing decades of expertise in the use of natural and synthetic materials for biomedical applications, the biomaterials community has the potential to play an especially instrumental role in developing new strategies or repurposing existing tools to prevent or treat complications resulting from the COVID-19 pathology. Leveraging microparticle- and nanoparticle-based technology, especially in pulmonary delivery, biomaterials have demonstrated the ability to effectively modulate inflammation and may be well-suited for resolving SARS-CoV-2-induced effects. Here, we provide an ove...Continue Reading

References

Jun 1, 1976·Environmental Health Perspectives·H C YehO G Raabe
Jul 21, 1998·JAMA : the Journal of the American Medical Association·G U MeduriE A Tolley
Nov 10, 2001·Annual Review of Biomedical Engineering·S L Diamond
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Deirdre P McIntoshJan E Schnitzer
Sep 3, 2003·Nature Reviews. Drug Discovery·Michael A PalladinoLyle L Moldawer
Sep 5, 2003·International Journal of Pharmaceutics·Hannele Eerikäinen, Esko I Kauppinen
Nov 18, 2003·British Journal of Clinical Pharmacology·N R Labiris, M B Dolovich
Aug 23, 2005·Proceedings of the American Thoracic Society·James F Donohue, Jill A Ohar
Oct 21, 2005·The New England Journal of Medicine·Turk Rhen, John A Cidlowski
Dec 3, 2005·Proceedings of the American Thoracic Society·Thomas R Martin, Charles W Frevert
Dec 13, 2005·Microbiology and Molecular Biology Reviews : MMBR·Susan R Weiss, Sonia Navas-Martin
Sep 14, 2006·PLoS Medicine·Lauren J StockmanPaul Garner
Oct 20, 2006·Trends in Immunology·Sai T ReddyJeffrey A Hubbell
Dec 30, 2006·Nature Reviews. Drug Discovery·John S Patton, Peter R Byron
May 11, 2007·Archives of Pharmacal Research·Qing-yu XiangYuan Huang
Dec 29, 2007·Seminars in Immunology·James M AndersonDavid T Chang
Mar 8, 2008·Advanced Drug Delivery Reviews·Laura J PeekCory Berkland
Mar 29, 2008·Annual Review of Immunology·Falk Nimmerjahn, Jeffrey V Ravetch
May 31, 2008·Nanomedicine·Tarek M FahmyW Mark Saltzman
Jun 14, 2008·Nature Reviews. Immunology·John A Hamilton
Nov 26, 2008·Paediatric Respiratory Reviews·Hayley See, Peter Wark
Dec 17, 2009·Archives of Internal Medicine·Marco Ho-Bun LamSiu-Ping Lam
Feb 13, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Mathieu GoutayerIsabelle Texier
Mar 27, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jenny C NgaiDavid S Hui
Apr 20, 2010·Molecular and Cellular Endocrinology·Agnes E Coutinho, Karen E Chapman
Sep 9, 2010·Expert Review of Vaccines·Moses O OyewumiZhengrong Cui
Oct 7, 2010·Expert Review of Vaccines·António RoldãoPaula M Alves
Feb 15, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Bram SlütterJoke A Bouwstra
May 24, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Anirban Sen Gupta
May 31, 2011·International Immunopharmacology·Roberto NicoleteLúcia H Faccioli
Dec 24, 2011·Journal of the American Chemical Society·Carl D WalkeyWarren C W Chan
Feb 22, 2012·Lung India : Official Organ of Indian Chest Society·J S Patil, S Sarasija
May 1, 2012·Pharmacological Reviews·José M MorachisAdah Almutairi
May 30, 2012·Advanced Materials·James J MoonDarrell J Irvine
Jul 4, 2012·The Science of the Total Environment·Adny Henrique SilvaTânia Beatiz Creczynski-Pasa
Sep 22, 2012·ACS Nano·Matthias BartneckFrank Tacke
Nov 13, 2012·International Journal of Nanomedicine·Eleonore Fröhlich
Dec 14, 2012·British Journal of Anaesthesia·W F S Sellers
Dec 25, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sheva NaahidiP Chen
Feb 26, 2013·Clinical and Experimental Pharmacology & Physiology·Sheila K PatelLouise M Burrell
Mar 28, 2013·Frontiers in Cellular and Infection Microbiology·Anthony E GregoryDiane Williamson

❮ Previous
Next ❯

Citations

May 11, 2021·ACS Biomaterials Science & Engineering·Erica B Peters, Rinti Banerjee
May 11, 2021·Frontiers in Pharmacology·G KanimozhiN Rajendra Prasad

❮ Previous
Next ❯

Methods Mentioned

BETA
electron microscopy
Infection
bronchoalveolar
lavage

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Related Papers

Signal Transduction and Targeted Therapy
Li YangYi Zhang
Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
Julianne D TwomeyBaolin Zhang
Critical Reviews in Clinical Laboratory Sciences
Victoria HigginsIoannis Prassas
© 2021 Meta ULC. All rights reserved