Biomaterials-based strategies for salivary gland tissue regeneration

Biomaterials Science
Tugba OzdemirXinqiao Jia

Abstract

The salivary gland is a complex, secretory tissue that produces saliva and maintains oral homeostasis. Radiation induced salivary gland atrophy, manifested as "dry mouth" or xerostomia, poses a significant clinical challenge. Tissue engineering recently has emerged as an alternative, long-term treatment strategy for xerostomia. In this review, we summarize recent efforts towards the development of functional and implantable salivary glands utilizing designed polymeric substrates or synthetic matrices/scaffolds. Although the in vitro engineering of a complex implantable salivary gland is technically challenging, opportunities exist for multidisciplinary teams to assemble implantable and secretory tissue modules by combining stem/progenitor cells found in the adult glands with biomimetic and cell-instructive materials.

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Citations

Mar 21, 2017·International Journal of Biological Macromolecules·Sharvari Vijaykumar Patil, Lalitha S Y Nanduri
Apr 8, 2020·Regenerative Medicine·Erum KhanZohaib Khurshid
Aug 5, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Nicholas G FischerConrado Aparicio
Aug 25, 2020·Tissue Engineering. Part a·Caitlynn M L BarrowsSimon Young
Oct 13, 2020·Journal of Dental Research·H T Dos SantosO J Baker
Dec 10, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuli ZhangSimon D Tran
Jan 23, 2021·Journal of Dental Research·X GaoW Tian
Apr 24, 2021·Materials Today. Bio·N Contessi NegriniA D Celiz
Dec 19, 2016·ACS Biomaterials Science & Engineering·Tugba OzdemirXinqiao Jia

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