Biomaterials in periodontal regenerative surgery: effects of cryopreserved bone, commercially available coral, demineralized freeze-dried dentin, and cementum on periodontal ligament fibroblasts and osteoblasts

Journal of Biomaterials Applications
Didem DevecioğluRahime M Nohutcu

Abstract

The ultimate goal of periodontal therapy is to achieve successful periodontal regeneration. The effects of different biomaterials, allogenic and alloplastic, used in periodontal surgeries to achieve regeneration have been studied in vitro on periodontal ligament (PDL) cells and MC3T3-E1 cells. The materials tested included cryopreserved bone allograft (CBA), coralline hydroxyapatite (CH), demineralized freeze-dried dentin (DFDD), and cementum. CBA and CH revealed an increase in initial PDL cell attachment, whereas CH resulted in an increase in long-term PDL cell attachment. Mineral-like nodule formation was observed significantly higher in DFDD compared to other materials tested for osteoblasts. Based on the results of this in vitro study, we conclude that the materials used are all biocompatible with human PDL cells and osteoblasts, which have pivotal importance in periodontal regeneration.

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Citations

May 16, 2008·Marine Biotechnology·Razi Vago
Dec 5, 2006·Journal of Materials Science. Materials in Medicine·Weibin SunHuating Zhao
Oct 29, 2009·Tissue Engineering. Part B, Reviews·Fa-Ming Chen, Yan Jin
Nov 26, 2008·Acta Odontologica Scandinavica·Pinar EmecenRahime Meral Nohutcu
Jul 25, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fa-ming ChenYan Jin
Nov 12, 2016·Injury·Ippokratis Pountos, Peter V Giannoudis
Jul 2, 2015·Journal of the Korean Association of Oral and Maxillofacial Surgeons·Mahdi KadkhodazadehReza Amid
Sep 16, 2018·Materials·Ana S Neto, José M F Ferreira
May 4, 2021·Journal of the Mechanical Behavior of Biomedical Materials·Satheesh Kumar BaluSampath V

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