BioMEA: a versatile high-density 3D microelectrode array system using integrated electronics

Biosensors & Bioelectronics
G CharvetBlaise Yvert

Abstract

Microelectrode arrays (MEAs) offer a powerful tool to both record activity and deliver electrical microstimulations to neural networks either in vitro or in vivo. Microelectronics microfabrication technologies now allow building high-density MEAs containing several hundreds of microelectrodes. However, dense arrays of 3D micro-needle electrodes, providing closer contact with the neural tissue than planar electrodes, are not achievable using conventional isotropic etching processes. Moreover, increasing the number of electrodes using conventional electronics is difficult to achieve into compact devices addressing all channels independently for simultaneous recording and stimulation. Here, we present a full modular and versatile 256-channel MEA system based on integrated electronics. First, transparent high-density arrays of 3D-shaped microelectrodes were realized by deep reactive ion etching techniques of a silicon substrate reported on glass. This approach allowed achieving high electrode aspect ratios, and different shapes of tip electrodes. Next, we developed a dedicated analog 64-channel Application Specific Integrated Circuit (ASIC) including one amplification stage and one current generator per channel, and analog output m...Continue Reading

Citations

Nov 19, 2011·Neural Computation·Jan PotworowskiDaniel Wójcik
Nov 1, 2011·Journal of Physiology, Paris·Sébastien Joucla, Blaise Yvert
May 16, 2015·Computational Intelligence and Neuroscience·Giulia RegaliaAlessandra Pedrocchi
Apr 19, 2012·Biotechnology and Bioengineering·E BiffiA Pedrocchi
Feb 2, 2013·Journal of Neuroscience Methods·Abduqodir H ToychievBotir T Sagdullaev
Dec 20, 2011·Journal of Neuroscience Methods·Andrew B KiblerDominique M Durand
Oct 28, 2014·Frontiers in Neuroengineering·Takashi Tateno, Jun Nishikawa
Aug 24, 2016·ELife·Sébastien RouxFrédéric Chavane
Feb 18, 2017·IEEE Transactions on Biomedical Circuits and Systems·Manuel Delgado-RestitutoAngel Rodriguez-Vazquez
Oct 5, 2017·Journal of Biomechanical Engineering·Lei ZuoJeffery Y Pan
Jan 25, 2020·Lab on a Chip·David A SosciaNicholas O Fischer
Feb 20, 2019·International Journal of Neural Systems·Marie Bernert, Blaise Yvert
May 21, 2021·Advanced Materials·Yo Han ChoJang-Ung Park
Jun 2, 2020·Journal of Neural Engineering·Andrea SpanuSergio Martinoia
Jul 20, 2021·ACS Biomaterials Science & Engineering·Avra KunduSwaminathan Rajaraman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Polyendocrine Syndromes

This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.