Biomechanical analysis of a synthetic, biodegradable impaction graft substitute

Journal of Biomedical Materials Research. Part a
Cameron LuttonBen Goss

Abstract

Impaction bone grafting in revision arthroplasty is a common and successful procedure to restore primary bone stock. Reducing the amount of bone needed to fill large grafts has been a driving force for the use of synthetic materials that can act as extenders or substitutes. To this end, we evaluated the mechanical properties of a new class of biodegradable polymer beads with and without donor bone to determine its suitability for use in impaction grafting. Biodegradable methacrylated anhydride beads were synthesized using thermal polymerization techniques. The mechanical properties of the beads were then tested in an impaction grafting test chamber and compared with morsellised porcine allograft. The beads, porcine allograft and a 50/50 combination all had similar mechanical properties, both in compression and relaxation. Pure polymer beads compacted significantly less than pure allograft and retained macroporosity after impaction. Our results suggest that the biodegradable beads have sufficient mechanical properties to be considered as an impaction grafting substitute or extender. Their ability to fill space whilst retaining macroporosity may be advantageous for tissue ingrowth and remodeling.

References

Nov 1, 1992·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·H WeinansH J Grootenboer
Dec 1, 1984·Acta Orthopaedica Scandinavica·T J SlooffA J Lemmens
Jan 1, 1993·The Journal of Bone and Joint Surgery. British Volume·G A GieA J Timperley
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J A Tamada, R Langer
Aug 1, 1997·The Journal of Arthroplasty·J D EldridgeI D Learmonth
May 9, 1998·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M D BrodtT D Brown
Jun 24, 1999·Journal of Biomedical Materials Research·D S MuggliK S Anseth
Dec 17, 2002·Journal of Biomedical Materials Research. Part a·Amy K PoshustaKristi S Anseth
Jul 28, 2004·The Journal of Bone and Joint Surgery. British Volume·H FreiT R Oxland
Sep 3, 2004·The Journal of Bone and Joint Surgery. American Volume·Andrew D TomsJan Herman Kuiper
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·B GrimmI G Turner
Sep 25, 2004·Journal of Biomechanics·L FosseL Grande
Nov 4, 2004·The Journal of Bone and Joint Surgery. American Volume·B Willem SchreursJean W M Gardeniers
Dec 21, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Hanspeter FreiThomas R Oxland
Mar 2, 2005·The Journal of Bone and Joint Surgery. British Volume·E H van HaarenI C Heyligers
May 23, 2006·Clinical Biomechanics·A DattaA W Miles
Mar 16, 2007·The Journal of Bone and Joint Surgery. British Volume·E H van HaarenP I J M Wuisman
Dec 3, 2008·Journal of Biomechanical Engineering·Knut B LundeBjørn Skallerud

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