Abstract
Fluid percussion injury (FPI) is a widely used experimental model for studying traumatic brain injury (TBI). However, little is known about how the brain mechanically responds to fluid impacts and how the mechanical pressures/strains of the brain correlate to subsequent brain damage for rodents during FPI. Hence, we developed a numerical approach to simulate FPI experiments on rats and characterize rat brain pressure/strain responses at a high resolution. A previous rat brain model was improved with a new hexahedral elements-based skull model and a new cerebrospinal fluid (CSF) layer. We validated the numerical model against experimentally measured pressures from FPI. Our results indicated that brain tissues under FPI experienced high pressures, which were slightly lower (10-20%) than input saline pressure. Interestingly, FPI was a mixed focus- and diffuse-type injury model with highest strains (12%) being concentrated in the ipsilateral cortex under the fluid-impact site and diffuse strains (5-10%) being spread to the entire brain, which was different from controlled cortical impact in which high strains decreased gradually away from the impact site.
References
Jan 1, 1992·Journal of Neurotrauma·L E ThibaultA Marmarou
Dec 13, 1991·Brain Research·D A HovdaD P Becker
Oct 1, 1991·Journal of Neuroscience Methods·C E DixonR L Hayes
Dec 1, 1991·Journal of Neurosurgery·R J HammR L Hayes
Jan 1, 1988·Journal of Neurotrauma·J W Lighthall
Jan 1, 1988·Journal of Neurotrauma·C E DixonT E Anderson
Jul 1, 1987·Journal of Neurosurgery·C E DixonR L Hayes
Jan 1, 1966·Biophysik·S Lindgren, L Rinder
Feb 1, 1994·Journal of Neurosurgery·A MarmarouK Demetriadou
Sep 2, 1996·Brain Research. Developmental Brain Research·M L PrinsD A Hovda
Feb 24, 1999·Journal of Neuropathology and Experimental Neurology·D I ShreiberD F Meaney
Jan 25, 2005·Journal of Neurotrauma·Hilaire J ThompsonTracy K McIntosh
May 19, 2005·Acta neurochirurgica·F Clausen, L Hillered
May 28, 2005·Brain Research·Jonathan E KurzSevern B Churn
Apr 8, 2010·Biomechanics and Modeling in Mechanobiology·Haojie MaoKai Yang
Sep 8, 2011·Journal of Neurotrauma·Yan LiJohn M Cavanaugh
Jan 19, 2013·Nature Reviews. Neuroscience·Ye XiongMichael Chopp
Sep 26, 2013·Journal of Biomechanical Engineering·Haojie MaoKing H Yang
Jul 6, 2014·Frontiers in Neurology·YungChia ChenDavid F Meaney
Aug 16, 2015·Behavioural Brain Research·Todd C PetersonMichael R Hoane
Citations
Dec 31, 2020·International Journal of Molecular Sciences·Agata CiechanowskaJoanna Mika
Nov 3, 2020·The Journal of Craniofacial Surgery·Brian T AndrewsRandolph J Nudo
Jul 6, 2021·Neurotrauma Reports·Joshua A BeitchmanRachel K Rowe
Jul 3, 2021·Journal of Neurotrauma·Douglas H SmithFiona Crawford
May 14, 2020·ACS Chemical Neuroscience·Dabin RenWei Chen
Jan 13, 2022·Journal of Neurotrauma·Ilknur ÖzenNiklas Marklund