Biomechanical analysis of structural deformation in living cells.

Medical & Biological Engineering & Computing
D L Bader, M M Knight

Abstract

Most tissues are subject to some form of physiological mechanical loading which results in deformation of the cells triggering intracellular mechanotransduction pathways. This response to loading is generally essential for the health of the tissue, although more pronounced deformation may result in cell and tissue damage. In order to determine the biological response of cells to loading it is necessary to understand how cells and intracellular structures deform. This paper reviews the various loading systems that have been adopted for studying cell deformation both in situ within tissue explants and in isolated cell culture systems. In particular it describes loading systems which facilitate visualisation and subsequent quantification of cell deformation. The review also describes the associated microscopy and image analysis techniques. The review focuses on deformation of chondrocytes with additional information on a variety of other cell types including neurons, red blood cells, epithelial cells and skin and muscle cells.

References

Aug 1, 1992·The Journal of Cell Biology·P LamoureuxS R Heidemann
Apr 1, 1991·The Journal of Cell Biology·P A JanmeyM Schliwa
Jan 1, 1989·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·R L SahJ D Sandy
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·N O PetersenE L Elson
May 1, 1995·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·F GuilakV C Mow
Jul 1, 1995·Physiological Reviews·P F Davies
Oct 1, 1994·BMJ : British Medical Journal·R K Vohra, C N McCollum
May 15, 1994·Archives of Biochemistry and Biophysics·Y J KimJ D Sandy
Jan 1, 1993·Methods in Cell Biology·L Majlof, P O Forsgren
Mar 1, 1997·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·D A Lee, D L Bader
Jun 13, 1998·Biotechnology Progress·G Vunjak-NovakovicL E Freed
Oct 26, 1999·Journal of Biomechanical Engineering·K D Costa, F C Yin
Dec 28, 1999·Journal of Biomechanics·T D Brown
Dec 28, 1999·Journal of Biomechanics·R M Hochmuth
Dec 28, 1999·Journal of Biomechanics·H MiyazakiK Hayashi
Mar 18, 2000·Biochemical and Biophysical Research Communications·F GuilakR Burgkart
Apr 4, 2001·Annals of Biomedical Engineering·C V BoutenD L Bade
Jul 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·N WangD E Ingber
Jun 8, 2002·Annals of Biomedical Engineering·Brian P Helmke, Peter F Davies
Jul 11, 2002·American Journal of Physiology. Cell Physiology·Tammo DelhaasLuc H E H Snoeckx
Jan 28, 2003·Journal of Biomechanics·Todd O McKinley, Brian K Bay
Feb 22, 2003·Journal of Biomechanics·Christopher C-B WangGerard A Ateshian

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Citations

Mar 7, 2009·Medical & Biological Engineering & Computing·L P LiW Herzog
Sep 5, 2009·Tissue Engineering. Part B, Reviews·Herman Vandenburgh
Jul 5, 2012·Journal of Biomechanical Engineering·Afshin Anssari-BenamHazel R C Screen
Jan 1, 2012·Journal of Functional Biomaterials·Reshma K TilwaniTina T Chowdhury
Jun 6, 2009·Journal of Applied Physiology·Axel GerstmairEdward Felder
Feb 6, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Semonti NandiJayant J Khandare
Mar 2, 2021·Chemical Society Reviews·Santanu Panja, Dave J Adams

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