Biomechanical and biochemical characterization of porcine tracheal cartilage

The Laryngoscope
Benjamin HoffmanJonathan Cheetham

Abstract

The trachea is essential to respiratory function and is a mechanically and biochemically complex composite tissue. Tissue-engineering approaches to treat tracheal diseases require detailed knowledge of the native mechanical and biochemical properties of the trachea. Although the porcine trachea represents an excellent preclinical model, relevant mechanical and biochemical composition are incompletely characterized. Experimental. The mechanical and biochemical properties of 12 intact porcine tracheas were determined to characterize their compliance, as well as the aggregate modulus, bidirectional elastic modulus, hydraulic permeability, and biochemical characteristics of individual cartilage rings. Data demonstrate the glycosaminoglycan content of tracheal rings was (mean ± standard deviation) 190 ± 49 μg/mg. Hydroxyproline content was 8.2 ± 3.2 μg/mg, and DNA content was 1.3 ± 0.27 μg/mg, a four-fold difference between circumferential elastic modulus (5.6 ± 2.0 megapascal [MPa]) and longitudinal composite elastic modulus (1.1 ± 0.7 MPa, P < 0.0001) was also observed. Aggregate modulus (stiffness) of porcine tracheal rings was 1.30 ± 0.28 MPa, and inflationary compliance was 0.00472 ± 0.00188 cmH2 O(-1) . This study presents a c...Continue Reading

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Citations

May 5, 2017·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Julien De WolfAlain Wurtz
Jan 6, 2018·Npj Regenerative Medicine·Kai Jen TsaiAchala de Mel
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Apr 9, 2018·ACS Biomaterials Science & Engineering·Elizabeth M Boazak, Debra T Auguste
Dec 11, 2017·ACS Biomaterials Science & Engineering·Elizabeth M BoazakDebra T Auguste

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