Biomechanical and biochemical outcomes of porcine temporomandibular joint disc deformation

Archives of Oral Biology
Andrea M MatuskaPeter S McFetridge

Abstract

The structure-function relationship in the healthy temporomandibular joint (TMJ) disc has been well established, however the changes in dysfunctional joints has yet to be systematically evaluated. Due to the poor understanding of the etiology of temporomandibular disorders (TMDs) this study evaluated naturally occurring degenerative remodeling in aged female porcine temporomandibular joint (TMJ) discs in order to gain insight into the progression and effects on possible treatment strategies of TMDs. Surface and regional biomechanical and biochemical properties of discal tissues were determined in grossly deformed (≥Wilkes Stage 3) and morphologically normal (≤Wilkes Stage 2) TMJ discs. Compared to normal disc structure the deformed discs lacked a smooth biconcave shape and characteristic ECM organization. Reduction in tensile biomechanical integrity and increased compressive stiffness and cellularity was found in deformed discs. Regionally, the posterior and intermediate zones of the disc were most frequently affected along with the inferior surface. The frequency of degeneration observed on the inferior surface of the disc (predominantly posterior), suggests that a disruption in the disc-condyle relationship likely contributes...Continue Reading

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Citations

Mar 22, 2018·Journal of Biomechanical Engineering·Jesse LoweAlejandro Almarza
Aug 25, 2017·Case Reports in Rheumatology·A Garza-AlpirezD A Galarza-Delgado
May 23, 2017·Journal of Dental Research·M C CoombsH Yao
Sep 29, 2018·Journal of Materials Science. Materials in Medicine·Andrea M MatuskaPeter S McFetridge
Mar 14, 2021·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Houssam AskarMohamed Hakim

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