Biomechanical Characterization of a Model of Noninvasive, Traumatic Anterior Cruciate Ligament Injury in the Rat

Annals of Biomedical Engineering
Tristan MaerzHoward W T Matthew

Abstract

The onset of post-traumatic osteoarthritis (PTOA) remains prevalent following traumatic joint injury such as anterior cruciate ligament (ACL) rupture, and animal models are important for studying the pathomechanisms of PTOA. Noninvasive ACL injury using the tibial compression model in the rat has not been characterized, and it may represent a more clinically relevant model than the common surgical ACL transection model. This study employed four loading profiles to induce ACL injury, in which motion capture analysis was performed, followed by quantitative joint laxity testing. High-speed, high-displacement loading repeatedly induces complete ACL injury, which causes significant increases in anterior-posterior and varus laxity. No loading protocol induced valgus laxity. Tibial internal rotation and anterior subluxation occurs up to the point of ACL failure, after which the tibia rotates externally as it subluxes over the femoral condyles. High displacement was more determinative of ACL injury compared to high speed. Low-speed protocols induced ACL avulsion from the femoral footprint whereas high-speed protocols caused either midsubstance rupture, avulsion, or a combination injury of avulsion and midsubstance rupture. This repeata...Continue Reading

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Citations

Feb 4, 2016·Journal of Orthopaedic Surgery and Research·Emmanuel L KuyinuCato T Laurencin
Sep 8, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Carina L BlakerElizabeth C Clarke
Mar 25, 2018·Scientific Reports·David BritzmanAnthony M J Bull
Jan 10, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Tristan MaerzKevin C Baker
Aug 23, 2019·Laboratory Animals·Brittany Y Jacobs, Kyle D Allen
Feb 20, 2018·Experimental and Therapeutic Medicine·Lei ZhangShijie Fu
Nov 5, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Tristan MaerzKevin C Baker
Nov 2, 2020·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Tamás OláhHenning Madry

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