Biomechanical characterization of vaginal versus abdominal surgical wound healing in the rabbit

American Journal of Obstetrics and Gynecology
Yoram AbramovPeter K Sand

Abstract

The objective of the study was to compare biomechanical properties of vaginal versus abdominal surgical wound healing in the rabbit. Bilateral 6-mm full-thickness circular segments were excised from the vagina and abdominal skin in 38 New Zealand White female rabbits. Animals were killed 0, 4, 7, 10, 14, 21, 28, and 35 days after wounding, and the wounds were assessed for surface area and tensile properties. Wound closure and scar contraction were significantly faster in the vagina than the abdomen (P = .001). Baseline tensile strength (P = .05), modulus (P = .001), and tensile energy to break (P = .18) were higher in the abdomen, whereas maximal tissue elongation was higher in the vagina (P = .13). After wounding, a drop in tensile strength, modulus, and tensile energy to break was observed in both tissues through postwounding day 4, followed by a progressive recovery of these properties. A progressive loss of elasticity was noted in both tissues after wounding. The surgical wound closes and contracts faster in the rabbit vagina than in its abdomen. Although these tissues have different biomechanical properties at baseline, they regenerate their tensile strength and lose their elasticity at a similar rate.

References

Jun 1, 1990·International Journal of Oral and Maxillofacial Surgery·J L RoodenburgP C Borsboom
Jan 1, 1995·Clinics in Plastic Surgery·D B Drake, S N Oishi
Sep 1, 1996·Burns : Journal of the International Society for Burn Injuries·J A ClarkK S Leung
Apr 1, 1997·Obstetrics and Gynecology·A L OlsenA L Clark
Jul 22, 1999·Experimental Cell Research·G Serini, G Gabbiani
Apr 11, 2003·The Journal of Urology·Andrew J WalterJeffrey L Cornella
Sep 11, 2003·Journal of Wound Care·M S AgrenJ Rygaard
Dec 31, 2003·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Yukiko OdaMinoru Ueda
Jan 30, 2004·American Journal of Obstetrics and Gynecology·Christopher F MaherPhilip J Schluter
May 19, 2004·American Journal of Surgery·Michael R Hausman, Brian D Rinker
Dec 14, 2004·The Journal of Biological Chemistry·Zhiyang GaoMasakiyo Sasahara
Jan 22, 2005·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Eric B TredgetAziz Ghahary
May 20, 2005·American Journal of Obstetrics and Gynecology·Yoram AbramovPeter K Sand

❮ Previous
Next ❯

Citations

Feb 10, 2010·International Urogynecology Journal·Matthew J AungstJohnnie Wright
Nov 30, 2015·Journal of the Mechanical Behavior of Biomedical Materials·S TodrosA N Natali
Dec 10, 2013·Journal of Minimally Invasive Gynecology·Jennifer KlauschieRosanne Kho
Oct 3, 2012·Journal of the Mechanical Behavior of Biomedical Materials·A GizziS Filippi
Jul 1, 2020·Advances in Wound Care·Jennifer M McCrackenJulie C-E Hakim
Jun 28, 2019·International Urogynecology Journal·David ShveikyKathryn Sandberg
Apr 3, 2012·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Yoram AbramovPeter K Sand

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
Yoram AbramovPeter K Sand
International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
A M El SamanM A Youssef
© 2022 Meta ULC. All rights reserved