Biomechanical evaluation of hMSCs-based engineered cartilage for chondral tissue regeneration

Journal of the Mechanical Behavior of Biomedical Materials
Fabiana GullottaFrancesca Gervaso

Abstract

Articular cartilage regeneration is still an open challenge in the field of tissue engineering. Although autologous chondrocytes seeded on collagen scaffolds (CSs) have already showed interesting results in the long-term repair of chondral lesions, they are not exempt from disadvantages that could be overcome using mesenchymal stem cells (MSCs). The ability of polymeric scaffolds to support MSCs proliferation and differentiation has been widely documented. However, few studies assessed their mechanical performances and additionally performing a single mechanical test, i.e. stress-strain or stress-relaxation in compression. Articular cartilage, though, possesses unique and multifaceted mechanical properties that can be exhaustively described only implementing a complete set of mechanical tests. Hence, the final aim of this study was to in depth assess the mechanical properties of human MSCs-cultured collagen scaffolds applying unconfined stress-strain, stress-relaxation and dynamic compression tests and identify key mechanical parameters. Firstly, plain CSs were fabricated and cultured under chondrogenic conditions with human MSCs (hMSCs). CSs displayed a high-interconnected porosity permitting uniform hMSCs distribution along t...Continue Reading

Citations

Jul 28, 2019·Journal of Tissue Engineering and Regenerative Medicine·Cristina ManferdiniGina Lisignoli
Nov 13, 2020·Tissue Engineering. Part B, Reviews·Wendy BalestriYvonne Reinwald

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