Biomechanical evaluation of the rabbit tibia after implantation of porous hydroxyapatite/collagen in a rabbit model

Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association
Tomokazu MasaokaShinichi Sotome

Abstract

Porous hydroxyapatite/collagen composite (HAp/Col) is an artificial bone substitute with excellent osteoconduction and sponge-like elasticity. However, the porosity of porous HAp/Col is as high as 95% and its mechanical strength is very poor. The aim of this study was to biomechanically analyze sites implanted with porous HAp/Col. Rectangular cortical bone defects (3 × 8 mm) were made in the tibia of rabbits and filled with porous HAp/Col or porous β-tricalcium phosphate or left vacant. The tibia was harvested at 4 or 12 weeks after surgery. The harvested specimens were analyzed using a micro-CT system, and the mechanical strength of the specimens was examined by torsion testing. Quantitative micro-CT analysis of the regenerated bone revealed that both bone substitutes equally facilitated bone regeneration. Biomechanical testing demonstrated that the torsional strength of HAp/Col-implanted sites was higher than that of the control (vs control: p = 0.030 and vs β-TCP: p = 0.056). The results indicate that porous HAp/Col implantation is an effective strategy for recovery of the mechanical strength of bone defects.

References

Jan 1, 1989·Journal of Orthopaedic Trauma·E M Younger, M W Chapman
Jul 3, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Naomi YamasakiAkira Myoui
Oct 6, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Yuichi KawasakiAtsushi Okawa
Jul 5, 2012·Archives of Orthopaedic and Trauma Surgery·Yusuke OkanoueMasanori Nakasu
Jul 6, 2012·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Kenichi GoshimaHiroyuki Tsuchiya

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Citations

Jun 27, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Niranjan RameshGeorge J Dias
Nov 7, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Satoru EgawaShinichi Sotome

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